Xanthohumol |
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| PRODUCT LINE | Natural Products / Antibiotics |
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| PRODUCT FAMILIES | Other Natural Products - DNA Regulation / Transcription |
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| Ordering Information |
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| Product Numbers | Format | Size | Unit Price | Quantity | | | ALX-350-280-M005 |
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5 mg | | | | | | |
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| Product Specification |
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| FORMULA: | C21H22O5 |
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| MW: | 354.4 |
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| CAS NUMBER: | 569-83-5, 6754-58-1 |
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| SOURCE/HOST: | Isolated from hops (Humulus lupulus). |
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| PURITY: | ≥98% (HPLC) |
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| APPEARANCE: | Yellow to orange powder. |
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| SOLUBILITY: | Soluble in DMSO (25mg/ml), methanol (10mg/ml) or 100% ethanol; soluble in aqueous buffers up to 20μM. |
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| SHIPPING: | AMBIENT |
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| LONG TERM STORAGE: | +4°C |
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| USE/STABILITY: | Stable as powder for at least 6 months when stored at +4°C in the dark. Stock solution made in DMSO should not be stored for longer than one month. Working solution is stable for 24 hours at 37°C and up to one week when stored at +4°C. Unstable in acidic (pH < 4.5) and alkaline (pH > 7.5) systems. |
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| IDENTITY: | Identity determined by NMR. |
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| Product Description |
Prenylated chalcone found in beer. Potent inhibitor of diacylglycerol acetyltransferase (DGAT). Inhibits DNA polymerase and induces cell differentiation. Has antiproliferative and cytotoxic effects in human cancer cell lines. Inhibits human P450 enzymes. Induces quinone reductase. Inhibits the expression of HIF-1α and VEGF under hypoxic conditions. Induces apoptosis in mature adipocytes. |
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| | Product Specific Literature References | Xanthohumols, diacylglycerol acyltransferase inhibitors, from Humulus lupulus: N. Tabata, et al.; Phytochemistry 46, 683 (1997) Abstract
Antiproliferative and cytotoxic effects of prenylated flavonoids from hops (Humulus lupulus) in human cancer cell lines: C.L. Miranda, et al.; Food Chem. Toxicol. 37, 271 (1999) Abstract
In vitro inhibition of human P450 enzymes by prenylated flavonoids from hops, Humulus lupulus: M.C. Henderson, et al.; Xenobiotica 30, 235 (2000) Abstract
Prenylated chalcones and flavanones as inducers of quinone reductase in mouse Hepa 1c1c7 cells: C.L. Miranda, et al.; Cancer Lett. 149, 21 (2000) Abstract
Cancer chemopreventive activity of Xanthohumol, a natural product derived from hop: C. Gerhauser, et al.; Mol. Cancer Ther. 1, 959 (2002) Abstract
Xanthohumol and related prenylflavonoids from hops and beer: to your good health!: J.F. Stevens & J.E. Page; Phytochemistry 65, 1317 (2004), (Review) Abstract
Effect of xanthohumol and isoxanthohumol on 3T3-L1 cell apoptosis and adipogenesis: J.Y. Yang, et al.; Apoptosis 12, 1953 (2007) Abstract |
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| RELATED PRODUCT GROUPS |
Natural Products / Antibiotics > Natural Products > Polyphenols (Flavonoids, Stilbenoids, Phenolic Acids) > Chalcones / Oxidative Stress > Respiratory Chain / Related Products > Respiratory Chain Other Products / Natural Products / Antibiotics > Natural Products > Natural Products - Apoptosis Inducers & Inhibitors / Chemokines & Cytokines > Growth Factors / Related Products > Vascular Endothelial Growth Factors [VEGFs] & Receptors [VEGF-Rs] / Related Products > VEGFs / Oxidative Stress > Hypoxia-inducible Factor [HIF] / Related Products / Natural Products / Antibiotics > Natural Products > Natural Products for Cancer Research > Natural Products - Antitumor Reagents / Natural Products / Antibiotics > Natural Products > Active Substances from Fruit and Vegetables / Cell Cycle > Stem Cells & Cell Differentiation > Cell Differentiation / Cancer > Antitumor Reagents > Antitumor Agents (Anti-proliferative) / Obesity & Adipokines > Lipid Metabolism / Related Products > Lipid Metabolism Other Products / Obesity & Adipokines > Obesity & Diabetes Other Products / DNA Regulation / Transcription > Nuclear Receptors / Related Products > Estrogen & Estrogen Receptors / Related Products |
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