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 ALX-350-280[ALEXIS] Revised 06-Jun-08  

Xanthohumol

PRODUCT LINE   

Natural Products / Antibiotics

PRODUCT FAMILIES   

Other Natural Products - DNA Regulation/Transcription

Ordering Information
 Product NumbersFormatSizeUnit PriceQuantity
 ALX-350-280-M005 5 mg  
Product Specification
FORMULA:   C21H22O5
 
MW:   354.4
 
CAS NUMBER:   569-83-5, 6754-58-1
 
SOURCE/HOST:   Isolated from hops (Humulus lupulus).
 
PURITY:   ≥98% (NMR)
 
APPEARANCE:   Yellow to orange powder.
 
SOLUBILITY:   Soluble in DMSO (25mg/ml) or methanol (10mg/ml).
 
SHIPPING:   AMBIENT
 
LONG TERM STORAGE:   +4°C

Product Description

Prenylated chalcone found in beer. Potent inhibitor of diacylglycerol acetyltransferase (DGAT), which catalyzes the final step in mammalian triacylglycerol synthesis. Inhibits DNA polymerase and induces cell differentiation. Has antiproliferative and cytotoxic effects in human cancer cell lines. Inhibits human P450 enzymes. Induces quinone reductase. Inhibits the expression of HIF-1α and VEGF under hypoxic conditions. Induces apoptosis in mature adipocytes.

Product Specific Literature References
Xanthohumols, diacylglycerol acyltransferase inhibitors, from Humulus lupulus: N. Tabata, et al.; Phytochemistry 46, 683 (1997) Abstract
Antiproliferative and cytotoxic effects of prenylated flavonoids from hops (Humulus lupulus) in human cancer cell lines: C.L. Miranda, et al.; Food Chem. Toxicol. 37, 271 (1999) Abstract
In vitro inhibition of human P450 enzymes by prenylated flavonoids from hops, Humulus lupulus: M.C. Henderson, et al.; Xenobiotica 30, 235 (2000) Abstract
Prenylated chalcones and flavanones as inducers of quinone reductase in mouse Hepa 1c1c7 cells: C.L. Miranda, et al.; Cancer Lett. 149, 21 (2000) Abstract
Cancer chemopreventive activity of Xanthohumol, a natural product derived from hop: C. Gerhauser, et al.; Mol. Cancer Ther. 1, 959 (2002) Abstract
Xanthohumol and related prenylflavonoids from hops and beer: to your good health!: J.F. Stevens & J.E. Page; Phytochemistry 65, 1317 (2004), (Review) Abstract
Effect of xanthohumol and isoxanthohumol on 3T3-L1 cell apoptosis and adipogenesis: J.Y. Yang, et al.; Apoptosis 12, 1953 (2007) Abstract
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