Actinonin |  | | SYNONYMS | 3[[1-[[2-(Hydroxymethyl)-1-pyrrolidinyl]-carbonyl]-2-methylpropyl]-carbamoyl]-octanohydroxamic acid | | | | PRODUCT LINE | Natural Products / Antibiotics | | | | PRODUCT FAMILIES | Antitumor Antibiotics | | | | | Ordering Information | | | Product Numbers | Format | Size | Unit Price | Quantity | | | ALX-260-128-M005 |
|
5 mg | | | | | | |
| | | Product Specification | | |
| FORMULA: | C19H35N3O5 | | | | | |
| MW: | 385.5 | | | | | |
| CAS NUMBER: | 13434-13-4 | | | | | |
| SOURCE/HOST: | Synthetic. | | | | | |
| PURITY: | ≥98% | | | | | |
| APPEARANCE: | White powder. | | | | | |
| SOLUBILITY: | Soluble in 100% ethanol. | | | | | |
| SHIPPING: | AMBIENT | | | | | |
| LONG TERM STORAGE: | -20°C | | | | | | Product Description | Inhibitor of aminopeptidase M, leucine aminopeptidase and deformylase. Shows antitumor activity. Apoptosis inducer. |
| | | Product Specific Literature References | Production of actinonin, an inhibitor of aminopeptidase M, by actinomycetes: H. Umezawa, et al.; J. Antibiot. (Tokyo) 38, 1629 (1985) Abstract
Analgesic effect of actinonin, a new potent inhibitor of multiple enkephalin degrading enzymes: M. Hachisu, et al.; Life Sci. 41, 235 (1987) Abstract
Effects of an antibiotic protease inhibitor, actinonin on the growth within collagen gels of non-metastatic and metastatic mouse mammary tumors of the same origin: K. Sayama, et al.; Cancer Lett 94, 171 (1995) Abstract
Inhibition of alanyl aminopeptidase induces MAP-kinase p42/ERK2 in the human T cell line KARPAS-299: U. Lendeckel, et al.; BBRC 252, 5 (1998) Abstract
Antitumor activity of actinonin in vitro and in vivo: Y. Xu, et al.; Clin. Cancer Res. 4, 171 (1998) Abstract
Actinonin, a naturally occurring antibacterial agent, is a potent deformylase inhibitor: D.Z. Chen, et al.; Biochemistry 39, 1256 (2000) Abstract
Human mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibiotics: M.D. Lee, et al.; J. Clin. Invest. 114, 1107 (2004) Abstract
Actinonin induces apoptosis in U937 leukemia cells: M. Grujic, et al.; Cancer Lett. 223, 211 (2005) Abstract |
| | | | | RELATED PRODUCT GROUPS | Signal Transduction > Signal Transduction Enzymes / Related Products > Proteases / Related Products > Aminopeptidases / Related Products / Cancer > Antitumor Reagents > Antitumor Agents (Enzyme Inhibitors) / Natural Products / Antibiotics > Natural Products > Natural Products - Apoptosis Inducers & Inhibitors | | | | | |
