(+)-Aeroplysinin-1 |  | | PRODUCT LINE | Natural Products / Antibiotics | | | | PRODUCT FAMILIES | Natural Products - Protein Kinase Inhibitors | | | | | Ordering Information | | | Product Numbers | Format | Size | Unit Price | Quantity | | | ALX-350-256-M001 |
|
1 mg | | | | | | |
| | | Product Specification | | |
| FORMULA: | C9H9Br2NO3 | | | | | |
| MW: | 339.0 | | | | | |
| CAS NUMBER: | 28656-91-9 | | | | | |
| SOURCE/HOST: | Isolated from Aplysina aerophoba. | | | | | |
| PURITY: | ≥97% | | | | | |
| APPEARANCE: | Oil. | | | | | |
| SOLUBILITY: | Soluble in 100% ethanol or DMSO. | | | | | |
| SHIPPING: | AMBIENT | | | | | |
| LONG TERM STORAGE: | -20°C | | | | | | Product Description | Displays cytostatic and cytotoxic activity. Inhibitor of EGFR kinase. Shows antiangiogenic activity. |
| | | Product Specific Literature References | Aeroplysinin-1, an antibacterial bromo-compound from the sponge Verongia aerophoba: E. Fattorusso, et al.; J. Chem. Soc. 1, 16 (1972) Abstract
Cytostatic activity of aeroplysinin-1 against lymphoma and epithelioma cells: M.H. Kreuter, et al.; Z. Naturforsch. [C] 44, 680 (1989) Abstract
Inhibition of intrinsic protein tyrosine kinase activity of EGF-receptor kinase complex from human breast cancer cells by the marine sponge metabolite (+)-aeroplysinin-1: M.H. Kreuter, et al.; Comp. Biochem. Physiol. B 97, 151 (1990) Abstract
Production of the cytostatic agent aeroplysinin by the sponge Verongia aerophoba in in vitro culture: M.H. Kreuter, et al.; Comp. Biochem. Physiol. 101C, 183 (1992) Abstract
Antibiotic and cytotoxic activity of brominated compounds from the marine sponge Verongia aerophoba: R. Teeyapant, et al.; Z. Naturforsch. [C] 48, 939 (1993) Abstract
Cytotoxicity and mode of action of aeroplysinin-1 and a related dienonefrom the sponge Aplysina aerophoba: A. Koulman, et al.; J. Nat. Prod. 59, 591 (1996) Abstract
Antiangiogenic activity of aeroplysinin-1, a brominated compound isolated from a marine sponge: S. Rodriguez-Nieto, et al.; FASEB J. 16, 261 (2002) Abstract |
| | | | | RELATED PRODUCT GROUPS | Signal Transduction > Kinases / Related Products > Tyrosine Kinases / Related Products > Tyrosine Kinase Inhibitors / Signal Transduction > Receptors > Receptor Tyrosine Kinases / Related Products > EGF / EGF Receptor [EGFR] Kinase / Related Products > EGFR Kinase Inhibitors / Natural Products / Antibiotics > Natural Products > Natural Products - Anti-infective Agents > Natural Products with Antibiotic Activity / Natural Products / Antibiotics > Natural Products > Natural Products for Cancer Research > Natural Products for Angiogenesis Research / Natural Products / Antibiotics > Natural Products > Natural Products for Cancer Research > Natural Products - Antitumor Reagents / Natural Products / Antibiotics > Natural Products > Marine Natural Products | | | | | |
