3-O-Acetyl-11-keto-β-boswellic acid |
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| SYNONYMS | AKβBA |
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| PRODUCT LINE | Natural Products / Antibiotics |
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| PRODUCT FAMILIES | Natural Products - Antitumor Reagents |
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| Ordering Information |
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| Product Numbers | Format | Size | Unit Price | Quantity | | | ALX-350-310-M005 |
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5 mg | | | | |  | |
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| Product Specification |
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| FORMULA: | C32H48O5 |
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| MW: | 512.7 |
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| CAS NUMBER: | 67416-61-9 |
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| SOURCE/HOST: | Isolated from Boswellia serrata. |
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| PURITY: | ≥99% (HPLC, NMR) |
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| APPEARANCE: | White to off-white solid. |
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| SOLUBILITY: | Soluble in acetone, dichloromethane, diethyl ether or DMSO. |
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| SHIPPING: | AMBIENT |
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| LONG TERM STORAGE: | -20°C |
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| USE/STABILITY: | Stock solutions are stable for up to 3 months when stored at -20°C. |
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| HANDLING: | Protect from light. |
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| HAZARD: | MAY BE CARCINOGENIC. HARMFUL. |
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| Product Description |
Shows antitumor and anti-inflammatory activities. Potent non-redox, noncompetitive 5-lipoxygenase and topoisomerase I and IIa inhibitor leading to apoptosis. 10-times more potent than 3-O-acetyl-β-boswellic acid (Prod. No. ALX-350-308). Exhibits in vivo efficacy in tumor growth and inhibition. |
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| | Product Specific Literature References | Acetyl-11-keto-beta-boswellic acid induces apoptosis in HL-60 and CCRF-CEM cells and inhibits topoisomerase I: R.F. Hoernlein, et al.; J. Pharmacol. Exp. Ther. 288, 613 (1999) Full Text; http://jpet.aspetjournals.org/cgi/reprint/288/2/613
Boswellic acids activate p42(MAPK) and p38 MAPK and stimulate Ca(2+) mobilization: A. Altmann, et al.; BBRC 290, 185 (2002) Abstract
Coupling of boswellic acid-induced Ca2+ mobilisation and MAPK activation to lipid metabolism and peroxide formation in human leucocytes: A. Altmann, et al.; Br. J. Pharmacol. 141, 223 (2004) Full Text; http://www.nature.com/bjp/journal/v141/n2/pdf/0705604a.pdf
Inhibition of IkappaB kinase activity by acetyl-boswellic acids promotes apoptosis in androgen-independent PC-3 prostate cancer cells in vitro and in vivo: T. Syrovets, et al.; J. Biol. Chem. 280, 6170 (2005) Full Text; http://www.jbc.org/cgi/reprint/280/7/6170
Boswellic acids: biological actions and molecular targets: D. Poeckel & O. Werz; Curr. Med. Chem. 13, 3359 (2006), Review Abstract
Mechanisms underlying the anti-inflammatory actions of boswellic acid derivatives in experimental colitis: C. Anthoni, et al.; Am. J. Physiol. Gastrointest. Liver Physiol. 290, G1131 (2006) Abstract
Potentiation of antinociceptive effect of NSAIDs by a specific lipooxygenase inhibitor, acetyl 11-keto-beta boswellic acid: M. Bishnoi, et al.; Indian J. Exp. Biol. 44, 128 (2006) Abstract |
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| Related Products |
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| | 3-O-Acetyl-β-boswellic acid | |
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| RELATED PRODUCT GROUPS |
Natural Products / Antibiotics > Natural Products > Natural Products - Signal Transduction Pathway Modulators > Natural Products - Protein Kinase Inhibitors / Cancer > Antitumor Reagents > Antitumor Agents (Apoptosis Inducers) / Natural Products / Antibiotics > Natural Products > Natural Products - Signal Transduction Pathway Modulators > Natural Products - NF-kB Pathway Inhibitors / Natural Products / Antibiotics > Natural Products > Natural Products - DNA Regulation / Transcription > Natural Products - Topoisomerase Inhibitors / Natural Products / Antibiotics > Natural Products > Natural Products for Inflammation Research > Natural Products - Anti-inflammatory Agents / Natural Products / Antibiotics > Natural Products > Natural Products - Apoptosis Inducers & Inhibitors / Signal Transduction > NF-kB Pathway > NF-kB Pathway Inhibitors / Inflammation > Eicosanoids / Related Products > Lipoxygenases / Related Products |
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