Alamethicin |
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| SYNONYMS | U-22324 |
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| PRODUCT LINE | Natural Products / Antibiotics |
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| PRODUCT FAMILIES | Antibiotics - Ionophores |
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| Ordering Information |
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| Product Numbers | Format | Size | Unit Price | Quantity | | | ALX-380-046-M001 |
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1 mg | | | | | ALX-380-046-M005 |
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5 mg | | | | | | |
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| Product Specification |
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| SEQUENCE: | Main component: Ac-Aib-Pro-Aib-Ala-Aib-Ala-Gln-Aib-Val-Aib-Gly-Leu-Aib-Pro-Val-Aib-Aib-Glu-Gln-Phl |
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| FORMULA: | C92H150N22O25 |
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| MW: | 1964.3 |
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| CAS NUMBER: | 27061-78-5, 59588-86-2 |
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| SOURCE/HOST: | Isolated from Trichoderma viride. |
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| PURITY: | ≥50% (remainder homologs) |
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| APPEARANCE: | Off-white to brown solid. |
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| SOLUBILITY: | Soluble in DMSO, 100% ethanol or methanol. |
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| SHIPPING: | AMBIENT |
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| LONG TERM STORAGE: | -20°C |
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| USE/STABILITY: | Solutions are stable for up to 3 months when stored at -20°C. |
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| HAZARD: | TOXIC. |
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| Product Description |
Membrane permeabilizing antibiotic. |
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| | Product Specific Literature References | The primary structure of alamethicin: J.W. Payne, et al.; Biochem. J. 117, 757 (1970) Abstract
Alamethicin-mediated fusion of lecithin vesicles: A.L.Y. Lau and S.I. Chan; PNAS 72, 2170 (1975) Abstract
The use of ionophores and channel formers in the study of the function of biological membranes: A. Gomez-Puyou & C. Gomez-Lojero; Curr. Top. Bioener. 6, 221 (1977)
The production of alamethicins by Trichoderma spp: D. Brewer, et al.; Can. J. Microbiol. 33, 619 (1987) Abstract
Model ion channels: gramicidin and alamethicin: G. A. Woolley & B. A. Wallace; J. Membr. Biol. 129, 109 (1992), Review Abstract
Ligand-induced extramembrane conformation switch controlling alamethicin assembly and the channel current: S. Futaki & K. Asami; Chem. Biodivers. 4, 1313 (2007), Review Abstract
Channel-forming activity of alamethicin: effects of covalent tethering: G.A. Woolley; Chem. Biodivers. 4, 1323 (2007), Review Abstract |
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