ω-Agatoxin IVA |  | | PRODUCT LINE | Natural Products / Antibiotics | | | | PRODUCT FAMILIES | Neurotoxins | | | | | Ordering Information | | | Product Numbers | Format | Size | Unit Price | Quantity | | | ALX-630-001-C100 |
|
100 µg | | | | | | |
| | | Product Specification | | |
| SEQUENCE: | H-Lys-Lys-Lys-Cys-Ile-Ala-Lys-Asp-Tyr-Gly-Arg-Cys-Lys-Trp-Gly-Gly-Thr-Pro-Cys-Cys-Arg-Gly-Arg-Gly-Cys-Ile-Cys-Ser-Ile-Met-Gly-Thr-Asn-Cys-Glu-Cys-Lys-Pro-Arg-Leu-Ile-Met-Glu-Gly-Leu-Gly-Leu-Ala-OH
(Disulfide bonds between Cys4-Cys20, Cys12-Cys25, Cys19-Cys36 and Cys27-Cys34) | | | | | |
| FORMULA: | C217H360N68O60S10 | | | | | |
| MW: | 5202.3 | | | | | |
| CAS NUMBER: | 145017-83-0 | | | | | |
| RTECS: | AW8050000 | | | | | |
| SOURCE/HOST: | Synthetic. Originally isolated from Agelenopsis aperta. | | | | | |
| PURITY: | ≥98% | | | | | |
| APPEARANCE: | Lyophilized. | | | | | |
| SOLUBILITY: | Soluble in water. | | | | | |
| SHIPPING: | AMBIENT | | | | | |
| LONG TERM STORAGE: | -20°C | | | | | |
| HAZARD: | HARMFUL. | | | | | | Product Description | Selective P-type Ca2+ channel blocker. Fast acting and potent eurotoxin. |
| | | Product Specific Literature References | P-type calcium channels blocked by the spider toxin omega-Aga-IVA: I.M. Mintz, et al.; Nature 355, 827 (1992) Abstract
Calcium channels coupled to glutamate release identified by omega-Aga- IVA: T.J. Turner, et al.; Science 258, 310 (1992) Abstract
Synthesis of omega-agatoxin IVA and its related peptides: H. Nishio, et al.; BBRC 196, 1447 (1993) Abstract
Interactions of polyamines with neuronal ion channels: R.H. Scott, et al.; TINS 16, 153 (1993), (Review) Abstract
Different types of calcium channels mediate central synaptic transmission: T. Takahashi & A. Momiyama; Nature 366, 156 (1993) Abstract
Sequential assignment and structure determination of spider toxin omega- Aga-IVB: H. Yu, et al.; Biochemistry 32, 13123 (1993) Abstract
Calcium channel diversity and neurotransmitter release: the omega-conotoxins and omega-agatoxins: B.M. Olivera, et al.; Ann. Rev. Biochem. 63, 823 (1994) Abstract
Exocytotic Ca2+ channels in mammalian central neurons: K. Dunlap, et al.; TINS 18, 89 (1995), (Review) Abstract
P/Q-type Ca2+ channel blocker omega-agatoxin IVA protects against brain injury after focal ischemia in rats: K. Asakura, et al.; Brain Res. 776, 140 (1997) Abstract
Agatoxin-IVA-sensitive calcium channels mediate the presynaptic and postsynaptic nicotinic activation of cardiac vagal neurons: J. Wang, et al.; J. Neurophysiol. 85, 164 (2001) Abstract |
| | | | | RELATED PRODUCT GROUPS | Signal Transduction > Ion Channels & Transporters / Related Products > Ca2+ Channels > Ca2+ Channels (P / Q-type) | | | | | |
