D,L-1'-Acetoxychavicol . acetate |  | | PRODUCT LINE | Natural Products / Antibiotics | | | | PRODUCT FAMILIES | Natural Products - Antitumor Reagents | | | | | Ordering Information | | | Product Numbers | Format | Size | Unit Price | Quantity | | | LKT-A0817-M025 |
|
25 mg | | | | | LKT-A0817-M100 |
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100 mg | | | | | LKT-A0817-M250 |
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250 mg | | | | | | |
| | | Product Specification | | |
| FORMULA: | C13H14O4 | | | | | |
| MW: | 234.3 | | | | | |
| CAS NUMBER: | 52946-22-2 | | | | | |
| LONG TERM STORAGE: | +20°C | | | | | | Product Description | A xanthine oxidase inhibitor shown to possess chemopreventive potential against both oral and colonic tumorigenesis in rat. Induces apoptosis. Inhibitor of nitric oxide production. |
| | | Product Specific Literature References | Acetoxychavicol acetate, an antifungal component of Alpinia galanga: A.M. Janssen & J.J. Scheffer; Planta Med. 507 (1985) Abstract
1´-Acetoxychavicol acetate as an inhibitor of phagocytosis of macrophages: N. Watanabe, et al.; Biosci. Biotechnol. Biochem. 59, 1566 (1995) Abstract
Chemopreventive effect of a xanthine oxidase inhibitor, 1'- acetoxychavicol acetate, on rat oral carcinogenesis: M. Ohnishi, et al.; Jpn. J. Cancer Res. 87, 349 (1996)
A xanthine oxidase inhibitor 1'-acetoxychavicol acetate inhibits azoxymethane-induced colonic aberrant crypt foci in rats: T. Tanaka, et al.; Carcinogenesis 18, 1113 (1997) Abstract
Inhibition by 1´-acetoxychavicol acetate of lipopolysaccharide- and interferon-gamma-induced nitric oxide production through suppression of inducible nitric oxide synthase gene expression in RAW264 cells: T. Ohata, et al.; Carcinogenesis 19, 1007 (1998) Abstract
Suppression of tumor promoter-induced oxidative stress and inflammatory responses in mouse skin by a superoxide generation inhibitor 1´-acetoxychavicol acetate: Y. Nakamura, et al.; Cancer Res. 58, 4832 (1998) Abstract
Apoptosis induced by 1´-acetoxychavicol acetate in Ehrlich ascites tumor cells is associated with modulation of polyamine metabolism and caspase-3 activation: J. Moffatt, et al.; Carcinogenesis 21, 2151 (2000) Full Text; http://carcin.oxfordjournals.org/cgi/reprint/21/12/2151
Induction of apoptosis in human myeloid leukemic cells by 1´-acetoxychavicol acetate through a mitochondrial- and Fas-mediated dual mechanism: K. Ito, et al.; Clin. Cancer Res. 10, 2120 (2004) Full Text; http://clincancerres.aacrjournals.org/cgi/reprint/10/6/2120
Structure-activity relationships of 1´S-1´-acetoxychavicol acetate for inhibitory effect on NO production in lipopolysaccharide-activated mouse peritoneal macrophages: H. Matsuda, et al.; Bioorg. Med. Chem. Lett. 15, 1949 (2005) Abstract
1´S-1´-Acetoxychavicol acetate as a new type inhibitor of interferon-beta production in lipopolysaccharide-activated mouse peritoneal macrophages: S. Ando, et al.; Bioorg. Med. Chem. 13, 3289 (2005) Abstract
1´-acetoxychavicol acetate is a novel nuclear factor kappaB inhibitor with significant activity against multiple myeloma in vitro and in vivo: K. Ito, et al.; Cancer Res. 65, 4417 (2005) Full Text; http://cancerres.aacrjournals.org/cgi/reprint/65/10/4417
Identification of a novel blocker of I kappa B alpha kinase that enhances cellular apoptosis and inhibits cellular invasion through suppression of NF-kappa B-regulated gene products: H. Ichikawa, et al.; J. Immunol. 174, 7383 (2005) Full Text; http://www.jimmunol.org/cgi/reprint/174/11/7383
1´-Acetoxychavicol acetate induces apoptosis of myeloma cells via induction of TRAIL: K. Ito, et al.; BBRC 338, 1702 (2005) Abstract
1´-Acetoxychavicol acetate inhibits RANKL-induced osteoclastic differentiation of RAW 264.7 monocytic cells by suppressing nuclear factor-kappaB activation: H. Ichikawa, et al.; Mol. Cancer Res. 4, 275 (2006) Abstract
1´S-1´-acetoxychavicol acetate isolated from Alpinia galanga inhibits human immunodeficiency virus type 1 replication by blocking Rev transport: Y. Ye & B. Li; J. Gen. Virol. 87, 2047 (2006) Abstract |
| | | | | RELATED PRODUCT GROUPS | Cancer > Antitumor Reagents > Antitumor Agents (Enzyme Inhibitors) / Natural Products / Antibiotics > Natural Products > Natural Products for Cancer Research > Natural Products - Chemopreventive Agents / Nitric Oxide Pathway > Nitric Oxide Synthases [NOS] / Related Products > NOS Inhibitors (NOS Induction & Enzyme Activity) | | | | | |
