Acivicin |  | | SYNONYMS | (αS,5S)-α-Amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid
U-42126
AT 125 | | | | PRODUCT LINE | Natural Products / Antibiotics | | | | PRODUCT FAMILIES | Antibiotics - Apoptosis Inducers & Inhibitors | | | | | Ordering Information | | | Product Numbers | Format | Size | Unit Price | Quantity | | | LKT-A0934-M010 |
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10 mg | | | | | LKT-A0934-M025 |
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25 mg | | | | | LKT-A0934-M100 |
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100 mg | | | | | | |
| | | Product Specification | | |
| FORMULA: | C5H7CIN2O3 | | | | | |
| MW: | 178.6 | | | | | |
| CAS NUMBER: | 42228-92-2 | | | | | | Product Description | Antibiotic glutamine analog. A specific inhibitor of γ-glutamyl transpeptidase and transmembrane glutathione transport. Potent antitumor and antileishmania agent. Induces apoptosis in human lymphoblastoid cells. Inhibitor of carbamoyl phosphate synthetase. |
| | | Product Specific Literature References | The inhibition of gamma-glutamyl transpeptidase from human pancreatic carcinoma cells by (alpha S,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125; NSC-163501): L. Allen, et al.; Res. Commun. Chem. Pathol. Pharmacol. 27, 175 (1980) Abstract
Excretion of cysteine and gamma-glutamylcysteine moieties in human and experimental animal gamma-glutamyl transpeptidase deficiency: O.W. Griffith & A. Meister; PNAS 77, 3384 (1980) Abstract
Apoptosis in human lymphoblastoid cells induced by acivicin, a specific gamma-glutamyltransferase inhibitor: R. Graber & G.A. Losa; Int. J. Cancer. 62, 443 (1995) Abstract
S-Nitrosoglutathione as a substrate for gamma-glutamyl transpeptidase: N. Hogg, et al.; Biochem. J. 323, 477 (1997) Abstract
Inactivation of the amidotransferase activity of carbamoyl phosphate synthetase by the antibiotic acivicin: B.W. Miles, et al.; J. Biol. Chem. 277, 4368 (2002) Full Text; http://www.jbc.org/cgi/reprint/277/6/4368
gamma-Glutamyl transpeptidase overexpression increases metastatic growth of B16 melanoma cells in the mouse liver: E. Obrador, et al.; Hepatology 35, 74 (2002) Abstract
Inhibition of gamma-glutamyl transpeptidase activity decreases intracellular cysteine levels in cervical carcinoma: P. Ruoso & D.W. Hedley; Cancer Chemother. Pharmacol. 54, 49 (2004) Abstract
Inhibition of T-cell proliferation by Helicobacter pylori gamma-glutamyl transpeptidase: C. Schmees, et al.; Gastroenterology 132, 1820 (2007) Abstract |
| | | | | RELATED PRODUCT GROUPS | Cancer > Antitumor Reagents > Antitumor Agents (Enzyme Inhibitors) / Natural Products / Antibiotics > Antibiotics > Antibiotics for Cancer Research > Antitumor Antibiotics / Cancer > Antitumor Reagents > Antitumor Agents (Apoptosis Inducers) | | | | | |
