Ellagic acid . dihydrate |  | | SYNONYMS | 4,4',5,5',6,6'-Hexahydroxydiphenic acid 2,6,2',6'-dilactone . 2H2O | | | | PRODUCT LINE | Natural Products / Antibiotics | | | | PRODUCT FAMILIES | Natural Products - Antioxidants | | | | | Ordering Information | | | Product Numbers | Format | Size | Unit Price | Quantity | | | ALX-270-262-M100 |
|
100 mg | | | | | | |
| | | Product Specification | | |
| FORMULA: | C14H6O8 . 2H2O | | | | | |
| MW: | 302.2 . 36.0 | | | | | |
| CAS NUMBER: | 476-66-4 | | | | | |
| MERCK INDEX: | 14: 3547 | | | | | |
| RTECS: | DJ2620000 | | | | | |
| SOURCE/HOST: | Isolated from chestnut bark. | | | | | |
| PURITY: | ≥97% | | | | | |
| APPEARANCE: | Grey to green solid. | | | | | |
| SOLUBILITY: | Soluble in 1M sodium hydroxide (10mg/ml) or pyridine. | | | | | |
| SHIPPING: | AMBIENT | | | | | |
| LONG TERM STORAGE: | +4°C | | | | | |
| HANDLING: | Protect from light. Keep under inert gas. | | | | | |
| HAZARD: | IRRITANT. | | | | | |
| IDENTITY: | Determined by MS and NMR. | | | | | | Product Description | Polyphenol antioxidant with antitumor properties. Inhibitor of topoisomerases. Inhibits VEGF-induced phosphorylation of VEGFR-2 and PDGF-induced phosphorylation of PDGFR. Induces apoptosis. |
| | | Product Specific Literature References | The dietary anticancer agent ellagic acid is a potent inhibitor of DNA topoisomerases in vitro: A. Constantinou, et al.; Nutr. Cancer 23, 121 (1995) Abstract
Novel inhibitors of 3-phosphoglycerate kinase: M.J. Hickey, et al.; Biochem. Soc. Trans. 23, 607S (1995) Abstract
Inhibitory actions of ellagic acid on growth and arylamide N-acetyltransferase activity in strains of Heliobacter pylori from peptic ulcer patients: J.G. Chung; Microbios 93, 115 (1998) Abstract
Polyphenols inhibit promotional phase of tumorigenesis: relevance of superoxide radicals: A. Kaul & K.L. Khanduja; Nutr. Cancer 32, 81 (1998) Abstract
Inhibition of eukaryote serine/threonine-specific protein kinases by piceatannol: B.H. Wang, et al.; Planta Med. 64, 195 (1998) Abstract
p53/p21 (WAF1CIP1) expression and its possible role in G1 arrest and apoptosis in ellagic acid treated cancer cells: B.A. Narayanan, et al.; Cancer Lett. 136, 215 (1999) Abstract
Combined inhibition of PDGF and VEGF receptors by ellagic acid, a dietary-derived phenolic compound: L. Labrecque, et al.; Carcinogenesis 26, 821 (2005) Abstract
Antioxidant and apoptosis-inducing activities of ellagic acid: D.H. Han, et al.; Anticancer Res. 26, 3601 (2006) Abstract
The efficacy of protective effects of tannic acid, gallic acid, ellagic acid, and propyl gallate against hydrogen peroxide-induced oxidative stress and DNA damages in IMR-90 cells: C.H. Chen, et al.; Mol. Nutr. Food Res. 51, 962 (2007) Abstract
Ellagic acid, a natural polyphenol protects rat peripheral blood lymphocytes against nicotine-induced cellular and DNA damage in vitro: with the comparison of N-acetylcysteine: A.R. Sudheer, et al.; Toxicology 230, 11 (2007) Abstract |
| | | | | RELATED PRODUCT GROUPS | Oxidative Stress > Antioxidants, Flavonoids & Free Radical Scavengers > Antioxidants, Flavonoids & Free Radical Scavengers Other Products / Cancer > Antitumor Reagents > Antitumor Agents (Enzyme Activators & Inducers) / Natural Products / Antibiotics > Natural Products > Natural Products - DNA Regulation / Transcription > Natural Products - Topoisomerase Inhibitors / Cancer > Antitumor Reagents > Antitumor Agents (Enzyme Inhibitors) / Natural Products / Antibiotics > Natural Products > Natural Products for Cancer Research > Natural Products - Antitumor Reagents / Natural Products / Antibiotics > Natural Products > Polyphenols (Flavonoids, Stilbenoids, Phenolic Acids) > Polyphenols Other Products / Natural Products / Antibiotics > Natural Products > Natural Products - Apoptosis Inducers & Inhibitors | | | | | |
