Doxycycline . monohydrate |
 |
| PRODUCT LINE | Natural Products / Antibiotics |
|
|
| PRODUCT FAMILIES | Antibiotics for Angiogenesis Research |
|
|
|
| Ordering Information |
|
| Product Numbers | Format | Size | Unit Price | Quantity | | | LKT-D5898-G001 |
|
1 g | | | | | LKT-D5898-G005 |
|
5 g | | | | | LKT-D5898-G010 |
|
10 g | | | | | LKT-D5898-G025 |
|
25 g | | | | | | |
|
|
| Product Specification |
|
|
| FORMULA: | C22H24N2O8 |
|
|
| |
|
| MW: | 444.4 |
|
|
| |
|
| CAS NUMBER: | 564-25-0 |
|
|
| |
|
| MERCK INDEX: | 13: 3474 |
|
|
|
|
| Product Description |
Doxycycline is a synthetic teracycline. Inhibits angiogenesis in a quantitative in vitro assay of angiogenesis [1]. Inhibits proliferation of the human leukemia cell line K562 [2]. It reduces lung metastases by inhibiting the secretion and activity of marrix metalloproteinases (MMPs) [3]. |
|
| | Product Specific Literature References | [1] MMP inhibition in prostate cancer: B.L. Lokeshwar; Ann. N. Y. Acad. Sci. 878, 271 (1999) Abstract
[2] Tetracycline-induced expression of an anti-c-Myb single-chain antibody and its inhibitory effect on proliferation of the human leukemia cell line K562: K. Kasono, et al.; Cancer Gene Ther. 7, 151 (2000) Abstract
[3] Effects of tetracyclines on angiogenesis in vitro: R.S. Fife, et al.; Cancer 153, 75 (2000) Abstract |
|
|
|
|
| RELATED PRODUCT GROUPS |
Cytoskeleton > Matrix Metalloproteinases [MMPs] / Related Products > MMP Inhibitors / Cancer > Antitumor Reagents > Antitumor Agents (Enzyme Inhibitors) / Natural Products / Antibiotics > Antibiotics > Antibiotics for Cancer Research > Antitumor Antibiotics / Cancer > Antitumor Reagents > Antitumor Agents (Anti-proliferative) |
|
|
|
