6BIO |  | | SYNONYMS | (2’Z,3’E)-6-Bromoindirubin-3’-oxime | | | | PRODUCT LINE | Signal Transduction | | | | PRODUCT FAMILIES | GSK-3 Inhibitors | | | | | Ordering Information | | | Product Numbers | Format | Size | Unit Price | Quantity | | | ALX-430-156-M001 |
|
1 mg | | | | |  | |
| | | Product Specification | | |
| FORMULA: | C16H10BrN3O2 | | | | | |
| MW: | 356.2 | | | | | |
| CAS NUMBER: | 667463-62-9 | | | | | |
| PURITY: | ≥98% | | | | | |
| APPEARANCE: | Dark red solid. | | | | | |
| SOLUBILITY: | Soluble in DMSO. | | | | | |
| SHIPPING: | AMBIENT | | | | | |
| LONG TERM STORAGE: | -20°C | | | | | |
| HANDLING: | Protect from light. | | | | | |
| HAZARD: | IRRITANT. | | | | | | Product Description | Inhibitor of phosphoinositide-dependent kinase 1 (PDK1). Potent, reversible and ATP-competitive inhibitor of glycogen synthase kinase-3α/β (GSK-3α/β). |
| | | Product Specific Literature References | Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases: P. Polychronopoulos, et al.; J. Med. Chem. 47, 935 (2004) Abstract
7-Bromoindirubin-3’-oxime induces caspase-independent cell death: J. Ribas, et al.; Oncogene 25, 6304 (2006) Abstract
Inverse in silico screening for identification of kinase inhibitor targets: S. Zahler, et al.; Chem. Biol. 14, 1207 (2007) Abstract
An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted indirubins: V. Myrianthopoulos, et al.; J. Med. Chem. 50, 4027 (2007) Abstract |
| | | | Related Products | | | | Indirubin-3'-monoxime | | | | 7BIO | | | | Me-7BIO | | | | Indirubin-5-sulfonic acid . sodium salt | | | | Indirubin | | | | 5-Iodo-indirubin-3'-monoxime | |
| | | | RELATED PRODUCT GROUPS | Signal Transduction > PI(3)K-Akt-mTOR Pathway > PI(3)K-Akt-mTOR Pathway Other Products | | | | | |
