trans-ACPD |  | | SYNONYMS | (±)-1-Aminocyclopentane-trans-1,3-dicarboxylic acid | | | | PRODUCT LINE | Neurobiology | | | | PRODUCT FAMILIES | Glutamate Receptors (Metabotropic) / Related Products | | | | | Ordering Information | | | Product Numbers | Format | Size | Unit Price | Quantity | | | ALX-550-020-M005 |
|
5 mg | | | | | ALX-550-020-M025 |
|
25 mg | | | | |  | |
| | | Product Specification | | |
| FORMULA: | C7H11NO4 | | | | | |
| MW: | 173.2 | | | | | |
| CAS NUMBER: | 67684-64-4, 39026-64-7 | | | | | |
| RTECS: | GY4060000 | | | | | |
| PURITY: | ≥97% (HPLC) | | | | | |
| APPEARANCE: | White to off-white powder. | | | | | |
| SOLUBILITY: | Soluble in dilute aqueous base or water. | | | | | |
| SHIPPING: | AMBIENT | | | | | |
| LONG TERM STORAGE: | +4°C | | | | | |
| HANDLING: | Protect from light. | | | | | |
| HAZARD: | HARMFUL. | | | | | |
| IDENTITY: | Identity determined by NMR. | | | | | | Product Description | Equimolar mixture of (1S,3R)-ACPD (Prod. No. ALX-550-021) and (1R,3S)-ACPD. Selective agonist for mGluRs (active at both group I and group II mGluRs). |
| | | Product Specific Literature References | The excitatory amino acid receptors: their classes, pharmacology, and distinct properties in the function of the central nervous system: D.T. Monaghan, et al.; Annu. Rev. Pharmacol. Toxicol. 29, 365 (1989) Abstract
Trans-ACPD, a selective agonist of the phosphoinositide-coupled excitatory amino acid receptor: E. Palmer, et al.; Eur. J. Pharmacol. 166, 585 (1989) Abstract
In vitro and in vivo pharmacology of trans- and cis-(+-)-1-amino-1,3-cyclopentanedicarboxylic acid: dissociation of metabotropic and ionotropic excitatory amino acid receptor effects: D.D. Schoepp, et al.; J. Neurochem. 56, 1789 (1991) Abstract
Molecular diversity of glutamate receptors and implications for brain function: S. Nakanishi; Science 258, 597 (1992) Abstract
Neuroprotective sigma ligands attenuate NMDA and trans-ACPD-induced calcium signaling in rat primary neurons: K.L. Klette, et al.; Brain Res. 756, 231 (1997) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review) Abstract
Metabotropic glutamate receptor agonists reduce glutamate release from cultured astrocytes: Z.C. Ye & H. Sontheimer; Glia 25, 270 (1999) Abstract |
| | | | Related Products | | | | (1S,3R)-ACPD | |
| | | | RELATED PRODUCT GROUPS | Neurobiology > Excitatory Amino Acids & Receptors > Excitatory Amino Acids | | | | | |
