(1S,3R)-ACPD |  | | SYNONYMS | (1S,3R)-1-Aminocyclopentane-1,3-dicarboxylic acid | | | | PRODUCT LINE | Neurobiology | | | | PRODUCT FAMILIES | Glutamate Receptors (Metabotropic) / Related Products | | | | | Ordering Information | | | Product Numbers | Format | Size | Unit Price | Quantity | | | ALX-550-021-M005 |
|
5 mg | | | | | ALX-550-021-M025 |
|
25 mg | | | | |  | |
| | | Product Specification | | |
| FORMULA: | C7H11NO4 | | | | | |
| MW: | 173.2 | | | | | |
| CAS NUMBER: | 111900-32-4 | | | | | |
| RTECS: | GY4060000 | | | | | |
| PURITY: | ≥97% (HPLC) | | | | | |
| APPEARANCE: | White to off-white powder. | | | | | |
| SOLUBILITY: | Soluble in dilute aqueous base or water. | | | | | |
| SHIPPING: | AMBIENT | | | | | |
| LONG TERM STORAGE: | +4°C | | | | | |
| HANDLING: | Protect from light. | | | | | |
| HAZARD: | HARMFUL. | | | | | |
| IDENTITY: | Identity determined by NMR. | | | | | | Product Description | Active isomer of trans-ACPD (Prod. No. ALX-550-020). |
| | | Product Specific Literature References | Synthesis, resolution, and absolute configuration of the isomers of the neuronal excitant 1-amino-1,3-cyclopentanedicarboxylic acid: K. Curry, et al.; J. Med. Chem. 31, 864 (1988) Abstract
Selective activation of phosphoinositide hydrolysis by a rigid analogue of glutamate: M.A. Desai & P.J. Conn; Neurosci. Lett. 109, 157 (1990) Abstract
1S,3R-ACPD stimulates and L-AP3 blocks Ca2+ mobilization in rat cerebellar neurons: A.J. Irving, et al.; Eur. J. Pharmacol. 186, 363 (1990) Abstract
Evidence for presynaptic depression of monosynaptic excitation in neonatal rat motoneurones by (1S,3S)- and (1S,3R)-ACPD: P.C. Pook, et al.; Exp. Physiol. 77, 529 (1992) Abstract
In vitro and in vivo pharmacology of 1S,3R- and 1R,3S-ACPD: evidence for a role of metabotropic glutamate receptors in striatal motor function: D.D. Schoepp; Mol. Neuropharmacol. 2, 33 (1992)
Seizures and brain injury in neonatal rats induced by 1S,3R-ACPD, a metabotropic glutamate receptor agonist: J.W. McDonald, et al.; J. Neurosci. 13, 4445 (1993) Abstract
Metabotropic glutamate receptors in brain function and pathology: D.D. Schoepp & P.J. Conn; TIPS 14, 13 (1993), (Review) Abstract
Intracerebral 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R- ACPD) produces limbic seizures that are not blocked by ionotropic glutamate receptor antagonists: J.P. Tizzano, et al.; Neurosci. Lett. 162, 12 (1993) Abstract
Metabotropic glutamate receptors: novel targets for drug development: T. Knöpfel, et al.; J. Med. Chem. 38, 1417 (1995) Abstract
Metabotropic glutamate receptors, transmitter output and fatty acids: studies in rat brain slices: G. Lombardi, et al.; Br. J. Pharmacol. 117, 189 (1996) Abstract
Differences in agonist and antagonist activities for two indices of metabotropic glutamate receptor-stimulated phosphoinositide turnover: R. Mistry & R.A. Challiss; Br. J. Pharmacol. 117, 1735 (1996) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review) Abstract |
| | | | Related Products | | | | trans-ACPD | |
| | | | RELATED PRODUCT GROUPS | Neurobiology > Excitatory Amino Acids & Receptors > Excitatory Amino Acids | | | | | |
