Aconitine |
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| SYNONYMS | (1α,3α,6α,14α,15α,16β)-20-Ethyl-1,6,16-trimethoxy-4-(methoxymethyl)aconitane-3,8,13,14,15-pentol 8-acetate 14-benzoate |
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| PRODUCT LINE | Natural Products / Antibiotics |
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| PRODUCT FAMILIES | Neurotoxins |
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| Ordering Information |
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| Product Numbers | Format | Size | Unit Price | Quantity | | | ALX-550-232-M025 |
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25 mg | | | | | | |
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| Product Specification |
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| FORMULA: | C34H47NO11 |
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| MW: | 645.7 |
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| CAS NUMBER: | 302-27-2 |
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| MERCK INDEX: | 14: 118 |
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| RTECS: | AR5960000 |
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| SOURCE/HOST: | Isolated from Aconitum karacolium. |
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| PURITY: | ≥98% |
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| APPEARANCE: | White to off-white powder. |
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| SOLUBILITY: | Soluble in 100% ethanol (35mg/ml); almost insoluble in water (0.3mg/ml). |
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| SHIPPING: | AMBIENT |
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| LONG TERM STORAGE: | +4°C |
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| HANDLING: | Protect from light. |
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| HAZARD: | VERY TOXIC. |
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| Product Description |
A lipid-soluble neurotoxin that acts as a sodium channel modulator. Blocks tetrodotoxin-sensitive Na+ channels. Potent neurotoxin. |
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| | Product Specific Literature References | Non-quantal acetylcholine release at mouse neuromuscular junction: effects of elevated quantal release and aconitine: S.P. Yu & W. Van der Kloot; Neurosci. Lett. 117, 111 (1990) Abstract
Synthesis and activity of a potent N-methyl-D-aspartic acid agonist, trans-1-aminocyclobutane-1,3-dicarboxylic acid, and related phosphonic and carboxylic acids: M. Muroi, et al.; Neuropharmacology 29, 567 (1990) Abstract |
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| RELATED PRODUCT GROUPS |
Natural Products / Antibiotics > Natural Products > Alkaloids / Signal Transduction > Ion Channels & Transporters / Related Products > Na+ Channels |
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