Soluble in DMSO. Pellet dry compound prior to DMSO addition. Solubilize at desired stock concentration.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Add from DMSO stock directly to in vitro or in vivo assay at desired concentration. Pre-incubation with compound prior to assay is recommended for maximal effect.
Product Description
Peptide aldehydes form a covalent hemiacetal adduct with the 20S proteasome, inhibiting the chymotrypsin-like peptidase activity. These inhibitors are reversible and cell-permeable, and also inhibit the activity of calpains and cathepsins.
Product Specific Literature References
Serine and cysteine proteinase inhibitors prevent nitric oxide production by activated macrophages by interfering with transcription of the inducible NO synthase gene: J.M. Griscavage, et al.; BBRC 215, 721 (1995) Abstract
General Information
Background/Technical Information
Please click here for the Original Manufacturer’s datasheet. Product description may differ slightly from Originals Manufacturer’s.
RELATED PRODUCT GROUPS
Signal Transduction > Calcium Signalling (Intracellular) > Calpains / Related Products / Cancer > Cathepsins / Related Products > Cathepsin Inhibitors
