AMT . hydrochloride |  | | SYNONYMS | 2-Amino-5,6-dihydro-6-methyl-4H-1,3-thiazine . HCl | | | | PRODUCT LINE | Nitric Oxide Pathway | | | | PRODUCT FAMILIES | NOS Inhibitors (NOS Induction & Enzyme Activity) | | | | | Ordering Information | | | Product Numbers | Format | Size | Unit Price | Quantity | | | ALX-270-033-M010 |
|
10 mg | | | | | ALX-270-033-M050 |
|
50 mg | | | | | | |
| | | Product Specification | | |
| FORMULA: | C5H10N2S . HCl | | | | | |
| MW: | 130.2 . 36.5 | | | | | |
| CAS NUMBER: | 1121-91-1 | | | | | |
| PURITY: | ≥98% | | | | | |
| APPEARANCE: | White to off-white solid. | | | | | |
| SOLUBILITY: | Soluble in water or 100% ethanol. | | | | | |
| SHIPPING: | AMBIENT | | | | | |
| LONG TERM STORAGE: | +4°C | | | | | |
| HAZARD: | IRRITANT. | | | | | | Product Description | Potent and selective inhibitor of inducible nitric oxide synthase (iNOS/NOS II). |
| | | Product Specific Literature References | Novel potent and selective inhibitors of inducible nitric oxide synthase: M. Nakane, et al.; Mol. Pharmacol. 47, 831 (1995) Abstract
In vivo pharmacological evaluation of two novel type II (inducible) nitric oxide synthase inhibitors: W.R. Tracey, et al.; Can. J. Physiol. Pharmacol. 73, 665 (1995) Abstract
Role of inducible nitric oxide synthase in regulation of pulmonary vascular tone in the late gestation ovine fetus: R.L. Rairigh, et al.; J. Clin. Invest. 101, 15 (1998) Abstract
Role of iNOS in the vasodilator responses induced by L-arginine in the middle cerebral artery from normotensive and hypertensive rats: A.M. Briones, et al.; Br. J. Pharmacol. 126, 111 (1999) Abstract
Salt-induced hypertension in Dahl salt-resistant and salt-sensitive rats with NOS II inhibition: M.A. Rudd, et al.; Am. J. Physiol. 277, H732 (1999) Abstract
The inhibitory potency and selectivity of arginine substrate site nitric-oxide synthase inhibitors is solely determined by their affinity toward the different isoenzymes: R. Boer, et al.; Mol. Pharmacol. 58, 1026 (2000) Full Text; http://molpharm.aspetjournals.org/cgi/reprint/58/5/1026
Inducible nitric oxide synthase inhibition attenuates renal hemodynamics during pregnancy: B.T. Alexander, et al.; Hypertension 39, 586 (2002) Abstract
Potential role of inducible nitric oxide synthase in the sleep-wake states occurrence in old rats: P. Clement, et al.; Neuroscience 135, 347 (2005) Abstract |
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