1400W . dihydrochloride |  | | SYNONYMS | N-(3-(Aminomethyl)benzyl)acetamidine . 2HCl | | | | PRODUCT LINE | Nitric Oxide Pathway | | | | PRODUCT FAMILIES | NOS Inhibitors (NOS Induction & Enzyme Activity) | | | | | Ordering Information | | | Product Numbers | Format | Size | Unit Price | Quantity | | | ALX-270-073-M005 |
|
5 mg | | | | | ALX-270-073-M025 |
|
25 mg | | | | | | |
| | | Product Specification | | |
| FORMULA: | C10H15N3 . 2HCl | | | | | |
| MW: | 177.3 . 73.0 | | | | | |
| PURITY: | ≥98% | | | | | |
| APPEARANCE: | White to off-white powder. | | | | | |
| SOLUBILITY: | Soluble in water, methanol or DMSO. | | | | | |
| SHIPPING: | AMBIENT | | | | | |
| LONG TERM STORAGE: | +4°C | | | | | |
| HANDLING: | Hygroscopic. | | | | | | Product Description | Highly selective inhibitor of inducible nitric oxide synthase (iNOS/NOS II) in vitro and in vivo. |
| | | Product Specific Literature References | 1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo: E.P. Garvey, et al.; J. Biol. Chem. 272, 4959 (1997) Full Text; http://www.jbc.org/cgi/content/full/272/8/4959
Selective inhibition of inducible nitric oxide synthase inhibits tumor growth in vivo: studies with 1400W, a novel inhibitor: L.L. Thomsen, et al.; Cancer Res. 57, 3300 (1997) Abstract
Actions of isoform-selective and non-selective nitric oxide synthase inhibitors on endotoxin-induced vascular leakage in rat colon: F. Laszlo & B.J.R. Whittle; Eur. J. Pharmacol. 334, 99 (1997) Abstract
The inhibitory potency and selectivity of arginine substrate site nitric-oxide synthase inhibitors is solely determined by their affinity toward the different isoenzymes: R. Boer, et al.; Mol. Pharmacol. 58, 1026 (2000) Full Text; http://molpharm.aspetjournals.org/cgi/reprint/58/5/1026
Nitric oxide synthases: structure, function and inhibition: W.K. Alderton, et al.; Biochem. J. 357, 593 (2001), Review Full Text; http://www.biochemj.org/bj/357/0593/3570593.pdf
Nitric Oxide Ameliorates Hydrophobic Bile Acid-induced Apoptosis in Isolated Rat Hepatocytes by Non-mitochondrial Pathways: E. Gumpricht, et al.; J. Biol. Chem. 277, 25823 (2002) Full Text; http://www.jbc.org/cgi/content/full/277/28/25823#SEC1
Structural basis for the specificity of the nitric-oxide synthase inhibitors W1400 and Nomega-propyl-L-Arg for the inducible and neuronal isoforms: R. Fedorov, et al.; J. Biol. Chem. 278, 45818 (2003) Full Text; http://www.jbc.org/cgi/reprint/278/46/45818
Increased vasoconstriction to noradrenaline by 1400W, inhibitor of iNOS, in rats with streptozotocin-induced diabetes: X. Cheng & C.C. Pang; Eur. J. Pharmacol. 484, 263 (2004) Abstract
1400W, a potent selective inducible NOS inhibitor, improves histopathological outcome following traumatic brain injury in rats: M. Jafarian-Tehrani, et al.; Nitric Oxide 12, 61 (2005) Abstract
Addition of nitric oxide donor S-nitroso-N-acetylcysteine to selective iNOS inhibitor 1400W further improves contractile function in reperfused skeletal muscle: J.U. Barker, et al.; Microsurgery 25, 338 (2005) Abstract
Effects of 1400W, a potent selective inducible NOS inhibitor, on histamine- and leukotriene D4-induced relaxation of isolated guinea pig nasal mucosa: Y. Chiba, et al.; Nitric Oxide 15, 142 (2006) Abstract |
| | | | | RELATED PRODUCT GROUPS | | | | | | |
