ABH . ammonium salt |  | | SYNONYMS | 2(S)-Amino-6-boronohexanoic acid . NH4 | | | | PRODUCT LINE | Nitric Oxide Pathway | | | | PRODUCT FAMILIES | Arginine & Arginases / Related Products | | | | | Ordering Information | | | Product Numbers | Format | Size | Unit Price | Quantity | | | ALX-270-420-M001 |
|
1 mg | | | | | ALX-270-420-M005 |
|
5 mg | | | | | | |
| | | Product Specification | | |
| FORMULA: | C6H13BNO4 . NH4 | | | | | |
| MW: | 174.0 . 18.0 | | | | | |
| PURITY: | ≥95.0% (1H-NMR) | | | | | |
| APPEARANCE: | White to off-white powder. | | | | | |
| SOLUBILITY: | Soluble in water. | | | | | |
| SHIPPING: | AMBIENT | | | | | |
| SHORT TERM STORAGE: | +4°C | | | | | |
| LONG TERM STORAGE: | -20°C | | | | | |
| USE/STABILITY: | Solutions are stable for 6 months when stored at -20°C. | | | | | |
| HANDLING: | Hygroscopic. After reconstitution, prepare aliquots and store at -20°C. | | | | | | Product Description | Potent and specific inhibitor of arginase. Does not inhibit NO synthases. |
| | | Product Specific Literature References | Inhibition of Mn2+ 2-arginase by borate leads to the design of a transition state analog inhibitor, 2(S)-amino-6-boronohexanoic acid: R. Baggio, et al.; J. Am. Chem. Soc. 119, 8107 (1997)
Biochemical and functional profile of a newly developed potent and isozyme-selective arginase inhibitor: R. Baggio, et al.; J. Pharmacol. Exp. Ther. 290, 1409 (1999) Full Text; http://jpet.aspetjournals.org/cgi/content/full/290/3/1409
Arginase-boronic acid complex highlights a physiological role in erectile function: J.D. Cox, et al.; Nat. Struct. Biol. 6, 1043 (1999) Abstract
Classical and slow-binding inhibitors of human type II arginase: D.M. Colleluori and D.E. Ash; Biochemistry (Mosc). 40, 9356 (2001) Abstract
Increased expression of arginase II in human diabetic corpus cavernosum: in diabetic-associated erectile dysfunction: T.J. Bivalacqua, et al.; BBRC 283, 923 (2001) Abstract
Arginase expression and modulation of IL-1beta-induced nitric oxide generation in rat and human islets of Langerhans: P. Stickings, et al.; Nitric Oxide 7, 289 (2002) Abstract
Arginase and autoimmune inflammation in the central nervous system: L. Xu, et al.; Immunology 110, 141 (2003) Full Text; http://www.blackwell-synergy.com/links/doi/10.1046/j.1365-2567.2003.01713.x/full/
Role of arginase in the male and female sexual arousal response: N.N. Kim, et al.; J. Nutr. 134, 2873S (2004) Full Text; http://jn.nutrition.org/cgi/reprint/134/10/2873S
Crystal structure of human arginase I at 1.29-A resolution and exploration of inhibition in the immune response: L. Di Costanzo, et al.; PNAS 102, 13058 (2005) Full Text; http://www.pnas.org/cgi/reprint/102/37/13058 |
| | | General Information | |
Background/Technical Information | | Note: Contains ~14% ammonium chloride. This does not affect activity, but must be taken into account for calculation of concentrations. | | |
| | | | RELATED PRODUCT GROUPS | | | | | | |
