Antimycin A |  | | SYNONYMS | Antipiricullin
Virosin | | | | PRODUCT LINE | Natural Products / Antibiotics | | | | PRODUCT FAMILIES | Antibiotics - Apoptosis Inducers & Inhibitors | | | | | Ordering Information | | | Product Numbers | Format | Size | Unit Price | Quantity | | | ALX-380-075-M005 |
|
5 mg | | | | | ALX-380-075-M010 |
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10 mg | | | | | | |
| | | Product Specification | | |
| CAS NUMBER: | 1397-94-0 | | | | | |
| MERCK INDEX: | 14: 714 (A1) & 715 (A3) | | | | | |
| RTECS: | CD0350000 | | | | | |
| SOURCE/HOST: | Isolated from Streptomyces sp. Mixture of antimycin A's. | | | | | |
| APPEARANCE: | White to faint yellow powder. | | | | | |
| SOLUBILITY: | Soluble in 100% ethanol (50mg/ml). | | | | | |
| SHIPPING: | AMBIENT | | | | | |
| LONG TERM STORAGE: | -20°C | | | | | |
| HANDLING: | Protect from light. | | | | | |
| HAZARD: | TOXIC. | | | | | | Product Description | Antibiotic. Induces apoptosis, which is not prevented by the presence of Bcl-2. Inhibits mitochondrial electron transport specifically between cytochromes b and c1. |
| | | Product Specific Literature References | The isolation and properties of antimycin A: B. R. Dunshee, et al.; J. Am. Chem. Soc. 71, 2436 (1949)
The effect of antimycin A on mouse liver inner mitochondrial membrane channel activity: M.L. Campo, et al.; J. Biol. Chem. 267, 8123 (1992) Full Text; http://www.jbc.org/cgi/reprint/267/12/8123.pdf
Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3: S.P. Tzung, et al.; Nat. Cell Biol. 3, 183 (2001) Abstract
Biophysical characterization of recombinant human Bcl-2 and its interactions with an inhibitory ligand, antimycin A: K.M. Kim, et al.; Biochemistry 40, 4911 (2001) Abstract
Synthetic peptides and non-peptidic molecules as probes of structure and function of Bcl-2 family proteins and modulators of apoptosis: D. Liu & Z. Huang; Apoptosis 6, 453 (2001) Abstract
Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3: S.P. Tzung, et al.; Nat. Cell. Biol. 3, 183 (2001) Abstract
Oligomycin and antimycin A prevent nitric oxide-induced apoptosis by blocking cytochrome C leakage: N. Dairaku, et al.; J. Lab. Clin. Med. 143, 143 (2004) Abstract
An ROS generator, antimycin A, inhibits the growth of HeLa cells via apoptosis: W.H. Park, et al.; J. Cell. Biochem. 102, 98 (2007) Abstract |
| | | | | RELATED PRODUCT GROUPS | Cell Death / Apoptosis / Autophagy > Mitochondrial Pathway > Bcl-2 Family Members / Related Products > Bcl-2 Family Modulators / Oxidative Stress > Respiratory Chain / Related Products > Respiratory Chain Other Products | | | | | |
