Atpenin A5 |  | | SYNONYMS | 3-[(2S,4S,5R)-5,6-Dichloro-2,4-dimethyl-1-oxohexyl]-4-hydroxy-5,6-dimethoxy-2(1H)-pyridinone | | | | PRODUCT LINE | Natural Products / Antibiotics | | | | PRODUCT FAMILIES | Antibiotics - Antifungal | | | | | Ordering Information | | | Product Numbers | Format | Size | Unit Price | Quantity | | | ALX-380-108-C250 |
|
250 µg | | | | | | |
| | | Product Specification | | |
| FORMULA: | C15H21Cl2NO5 | | | | | |
| MW: | 366.2 | | | | | |
| CAS NUMBER: | 119509-24-9 | | | | | |
| RTECS: | CJ8800000 | | | | | |
| SOURCE/HOST: | Produced by Penicillium sp. | | | | | |
| PURITY: | ≥85% (HPLC) | | | | | |
| APPEARANCE: | Colorless oil. | | | | | |
| SOLUBILITY: | Soluble in DMSO, methanol or 100% ethanol; insoluble in water. | | | | | |
| SHIPPING: | AMBIENT | | | | | |
| LONG TERM STORAGE: | -20°C | | | | | | Product Description | Antibiotic. Potent and specific inhibitor of mitochondrial complex II (succinate-ubiquinone oxidoreductase). |
| | | Product Specific Literature References | Atpenins, new antifungal antibiotics produced by Penicillium sp. Production, isolation, physico-chemical and biological properties: S. Omura, et al.; J. Antibiot. 41, 1769 (1988) Abstract
The structures of atpenins A4, A5 and B, new antifungal antibiotics produced by Penicillium sp: H. Kumagai, et al.; J. Antibiot. 43, 1553 (1990) Abstract
Mechanism of action of atpenin B on Raji cells: K. Oshino, et al.; J. Antibiot. 43, 1064 (1990) Abstract
Atpenins, potent and specific inhibitors of mitochondrial complex II (succinate-ubiquinone oxidoreductase): H. Miyadera, et al.; PNAS 100, 473 (2003) Abstract
Structural and computational analysis of the quinone-binding site of complex II (succinate-ubiquinone oxidoreductase): a mechanism of electron transfer and proton conduction during ubiquinone reduction: R. Horsefield, et al.; J. Biol. Chem. 281, 7309 (2006) Full Text; http://www.jbc.org/cgi/reprint/281/11/7309 |
| | | | | RELATED PRODUCT GROUPS | Oxidative Stress > Respiratory Chain / Related Products > Respiratory Chain Other Products | | | | | |
