Apoptolidin |
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| PRODUCT LINE | Natural Products / Antibiotics |
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| PRODUCT FAMILIES | Antibiotics - Apoptosis Inducers & Inhibitors |
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| Ordering Information |
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| Product Numbers | Format | Size | Unit Price | Quantity | | | ALX-380-207-MC01 |
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0.1 mg | | | | | | |
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| Product Specification |
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| FORMULA: | C58H96O21 |
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| MW: | 1129.4 |
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| CAS NUMBER: | 194874-06-1 |
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| SOURCE/HOST: | Isolated from Amicolatopsis sp. MST-AS5912. |
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| PURITY: | ≥95% (HPLC) |
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| APPEARANCE: | White to off-white solid. |
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| SOLUBILITY: | Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO. |
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| SHIPPING: | AMBIENT |
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| LONG TERM STORAGE: | -20°C |
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| HAZARD: | HARMFUL. |
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| Product Description |
Originally isolated from Nocardiopsis sp. Antibiotic. Potent and highly selective apoptosis inducer in several cancer cell lines. F0F1-ATPase inhibitor. |
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| | Product Specific Literature References | Apoptolidin, a new apoptosis inducer in transformed cells from Nocardiopsis sp: J.W. Kim, et al.; J. Antibiot. (Tokyo) 50, 6628 (1997) Abstract
Understanding and exploiting the mechanistic basis for selectivity of polyketide inhibitors of F(0)F(1)-ATPase: A.R. Salomon, et al.; PNAS 97, 14766 (2000) Full Text; http://www.pnas.org/cgi/content/full/97/26/14766
Apoptolidin, a selective cytotoxic agent, is an inhibitor of F0F1-ATPase: A.R. Salomon, et al.; Chem. Biol. 8, 71 (2001) Full Text; http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6VRP-42D2KY4-7&_user=10&_coverDate=01%2F31%2F2001&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=ecb932eefec6d3858f6e8a531e7e868c
Apoptolidin: induction of apoptosis by a natural product: P.T. Daniel, et al.; Angew. Chem. Int. Ed. Engl. 45, 872 (2006) Abstract
Correlation of F0F1-ATPase inhibition and antiproliferative activity of apoptolidin analogues: P.A. Wender, et al.; Org. Lett. 8, 589 (2006) Abstract |
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| RELATED PRODUCT GROUPS |
Natural Products / Antibiotics > Antibiotics > Antibiotics for Cancer Research > Antitumor Antibiotics / Natural Products / Antibiotics > Natural Products > Natural Products - Signal Transduction Pathway Modulators > Natural Products - ATPase Inhibitors / Cancer > Antitumor Reagents > Antitumor Agents (Apoptosis Inducers) / Oxidative Stress > Respiratory Chain / Related Products > Respiratory Chain Other Products |
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