Apigenin |  | | SYNONYMS | 4',5,7-Trihydroxyflavone | | | | PRODUCT LINE | Natural Products / Antibiotics | | | | PRODUCT FAMILIES | Flavones | | | | | Ordering Information | | | Product Numbers | Format | Size | Unit Price | Quantity | | | ALX-385-008-M010 |
|
10 mg | | | | | ALX-385-008-M050 |
|
50 mg | | | | | | |
| | | Product Specification | | |
| FORMULA: | C15H10O5 | | | | | |
| MW: | 270.2 | | | | | |
| CAS NUMBER: | 520-36-5 | | | | | |
| MERCK INDEX: | 14: 730 | | | | | |
| SOURCE/HOST: | Synthetic. | | | | | |
| PURITY: | ≥90% (HPLC) | | | | | |
| APPEARANCE: | Light yellow to slightly brown powder. | | | | | |
| SOLUBILITY: | Soluble in diluted potassium hydroxide or DMSO; slightly soluble in 100% ethanol (hot). Insoluble in water. | | | | | |
| SHIPPING: | AMBIENT | | | | | |
| LONG TERM STORAGE: | +4°C | | | | | |
| HAZARD: | IRRITANT. | | | | | | Product Description | Antioxidant flavonoid. Has chemopreventive and antitumor properties. Induces apoptosis. Inhibits the proliferation of malignant tumor cells by G2/M arrest. MAP kinase (MAPK/ERK) inhibitor. Inhibits hypoxia-inducible factor-1 (HIF-1) and vascular endothelial growth factor (VEGF) expression. |
| | | Product Specific Literature References | Apigenin and tangeretin enhance gap junctional intercellular communication in rat liver epithelial cells: C. Chaumontet, et al.; Carcinogenesis 15, 2325 (1994) Abstract
Apigenin induces morphological differentiation and G2-M arrest in rat neuronal cells: F. Sato, et al.; BBRC 204, 578 (1994) Abstract
Reversion of v-H-ras-transformed NIH 3T3 cells by apigenin through inhibiting mitogen activated protein kinase and its downstream oncogenes: M.L. Kuo and N.C. Yang; BBRC 212, 767 (1995) Abstract
Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Apigenin inhibits endothelial-cell proliferation in G(2)/M phase whereas it stimulates smooth-muscle cells by inhibiting P21 and P27 expression: V. Trochon, et al.; Int. J. Cancer 85, 691 (2000) Abstract
Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma: R. Torkin, et al.; Mol. Cancer Ther. 4, 1 (2005) Abstract
Apigenin and cancer chemoprevention: progress, potential and promise: D. Patel, et al.; Int. J. Oncol. 30, 233 (2007), (Review) Abstract
Apigenin inhibits tumor angiogenesis through decreasing HIF-1alpha and VEGF expression: J. Fang, et al.; Carcinogenesis 28, 858 (2007) Abstract
Apigenin-induced cell cycle arrest is mediated by modulation of MAPK, PI3K-Akt, and loss of cyclin D1 associated retinoblastoma dephosphorylation in human prostate cancer cells: S. Shukla & S. Gupta; Cell Cycle 6, 1102 (2007) Abstract
Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation: C. Nicholas, et al.; J. Immunol. 179, 7121 (2007) Abstract |
| | | | | RELATED PRODUCT GROUPS | Signal Transduction > MAP Kinase Pathways > MAPK Pathway Inhibitors / Cancer > Antitumor Reagents > Antitumor Agents (Anti-proliferative) / Chemokines & Cytokines > Growth Factors / Related Products > Vascular Endothelial Growth Factors [VEGFs] & Receptors [VEGF-Rs] / Related Products > VEGFs & VEGF-Rs Other Products / Natural Products / Antibiotics > Natural Products > Natural Products for Cancer Research > Natural Products for Angiogenesis Research / Natural Products / Antibiotics > Natural Products > Natural Products - Signal Transduction Pathway Modulators > Natural Products - Protein Kinase Inhibitors / Natural Products / Antibiotics > Natural Products > Natural Products for Cancer Research > Natural Products - Chemopreventive Agents / Natural Products / Antibiotics > Natural Products > Natural Products - Antioxidants / Natural Products / Antibiotics > Natural Products > Natural Products for Cancer Research > Natural Products - Antitumor Reagents / Natural Products / Antibiotics > Natural Products > Natural Products - Apoptosis Inducers & Inhibitors / Cancer > Antitumor Reagents > Antitumor Agents (Enzyme Inhibitors) / Oxidative Stress > Hypoxia-inducible Factor [HIF] / Related Products | | | | | |
