Baicalein |  | | SYNONYMS | 5,6,7-Trihydroxyflavone | | | | PRODUCT LINE | Natural Products / Antibiotics | | | | PRODUCT FAMILIES | Flavones | | | | | Ordering Information | | | Product Numbers | Format | Size | Unit Price | Quantity | | | ALX-385-022-M005 |
|
5 mg | | | | | ALX-385-022-M025 |
|
25 mg | | | | | | |
| | | Product Specification | | |
| FORMULA: | C15H10O5 | | | | | |
| MW: | 270.2 | | | | | |
| CAS NUMBER: | 491-67-8 | | | | | |
| MERCK INDEX: | 14: 942 | | | | | |
| PURITY: | ≥97% | | | | | |
| APPEARANCE: | Yellow to yellow-green crystalline powder. | | | | | |
| SOLUBILITY: | Soluble in DMSO, 100% ethanol or methanol; almost insoluble in water. | | | | | |
| SHIPPING: | AMBIENT | | | | | |
| LONG TERM STORAGE: | -20°C | | | | | |
| HANDLING: | Protect from light. | | | | | |
| HAZARD: | IRRITANT. | | | | | | Product Description | Inhibitor of 12-lipoxygenase, leukotriene biosynthesis and the release of lysosomal enzymes. Inhibits cellular Ca2+ uptake and calcium mobilization. Inhibitor of protein tyrosine kinase in leukemia (CEM) cells. Induces cell cycle arrest and apoptosis. Anti-inflammatory compound. Has anti-thrombotic, anti-proliferative and anti-mitogenic effects. |
| | | Product Specific Literature References | Specific action of the lipoxygenase pathway in mediating angiotensin II- induced aldosterone synthesis in isolated adrenal glomerulosa cells: J.L. Nadler, et al.; J. Clin. Invest. 80, 1763 (1987) Abstract
Inhibition of reverse transcriptase activity by a flavonoid compound, 5,6,7-trihydroxyflavone: K. Ono, et al.; BBRC 160, 982 (1989) Abstract
Biliary excretion of metabolites of baicalin and baicalein in rats: K. Abe, et al.; Chem. Pharm. Bull. 38, 209 (1990) Abstract
Effects of baicalein and esculetin on transduction signals and growth factors expression in T-lymphoid leukemia cells: H.C. Huang, et al.; Eur. J. Pharmacol. 268, 73 (1994) Abstract
Protective effects of baicalein against cell damage by reactive oxygen species: D. Gao, et al.; Chem. Pharm. Bull. (Tokyo) 46, 1383 (1998) Abstract
Baicalein induces a dual growth arrest by modulating multiple cell cycle regulatory molecules : S.L. Hsu, et al.; Eur. J. Pharmacol. 425, 165 (2001) Abstract
Mechanisms in mediating the anti-inflammatory effects of baicalin and baicalein in human leukocytes: Y.C. Shen, et al.; Eur. J. Pharmacol. 465, 171 (2003) Abstract
Baicalein induced cell cycle arrest and apoptosis in human lung squamous carcinoma CH27 cells: H.Z. Lee, et al.; Anticancer Res. 25, 959 (2005) Abstract
Biological properties of baicalein in cardiovascular system: Y. Huang, et al.; Curr. Drug Targets Cardiovasc. Haematol. Disord. 5, 177 (2005), (Review) Abstract
Baicalein inhibition of hydrogen peroxide-induced apoptosis via ROS-dependent heme oxygenase 1 gene expression: H.Y. Lin, et al.; Biochim. Biophys. Acta 1773, 1073 (2007) Abstract |
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