ACP |  | | SYNONYMS | 1-Acetoxy-3-carbamoyl-2,2,5,5-tetramethylpyrrolidine | | | | PRODUCT LINE | Oxidative Stress | | | | PRODUCT FAMILIES | Oxidative Stress Markers & Reagents / Related Products | | | | | Ordering Information | | | Product Numbers | Format | Size | Unit Price | Quantity | | | ALX-430-118-M010 |
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10 mg | | | | | ALX-430-118-M050 |
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50 mg | | | | | ALX-430-118-M250 |
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250 mg | | | | | | |
| | | Product Specification | | |
| FORMULA: | C11H20N2O3 | | | | | |
| MW: | 228.3 | | | | | |
| PURITY: | ≤0.05% paramagnetic impurities (by EPR) | | | | | |
| APPEARANCE: | White to off-white crystalline powder. | | | | | |
| SOLUBILITY: | Soluble in water, methanol, 100% ethanol or DMSO. | | | | | |
| SHIPPING: | SHIPPED ON BLUE ICE | | | | | |
| LONG TERM STORAGE: | -20°C | | | | | | Product Description | Cell permeable probe for the detection of intracellular oxidative stress. ACP can easily be deprotected with esterases to cyclic hydroxylamines, which are oxidized by ROS leading to ESR-detectable nitroxide radicals. |
| | | Product Specific Literature References | Sensitive ESR determination of intracellular oxidative stress by using acyl-protected hydroxylamines as new spin reagents: O. Itoh, et al.; Chem. Lett. 304 (2000)
In vivo EPR imaging by using an acyl-protected hydroxylamine to analyze intracerebral oxidative stress in rats after epileptic seizures: H. Yokoyama, et al.; Magn. Reson. Imaging 18, 875 (2000) Abstract
Measurement of oxidative stress by EPR radical-probe technique: L. Valgimigli, et al.; Free Radical Biol. Med. 31, 708 (2001), (Review) Abstract
Pharmacokinetic study of acyl-protected hydroxylamine probe, 1-acetoxy-3-carbamoyl-2,2,5,5-tetramethylpyrrolidine, for in vivo measurements of reactive oxygen species: K. Saito, et al.; Free Radic. Biol. Med. 36, 517 (2004) Abstract |
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