N-Acetyl-Asp-Glu-OH |  | | SYNONYMS | α-NAAG
Spaglumic acid | | | | PRODUCT LINE | Neurobiology | | | | PRODUCT FAMILIES | Glutamate Receptors (Metabotropic) / Related Products | | | | | Ordering Information | | | Product Numbers | Format | Size | Unit Price | Quantity | | | ALX-151-020-M010 |
|
10 mg | | | | | ALX-151-020-M050 |
|
50 mg | | | | | | |
| | | Product Specification | | |
| FORMULA: | C11H16N2O8 | | | | | |
| MW: | 304.3 | | | | | |
| CAS NUMBER: | 3106-85-2 | | | | | |
| PURITY: | ≥98% | | | | | |
| SOLUBILITY: | Soluble in water. | | | | | |
| SHIPPING: | AMBIENT | | | | | |
| LONG TERM STORAGE: | +4°C | | | | | | Product Description | Endogenous neurotransmitter with high affinity for the brain glutamate receptor. N-acetylated α-linked acidic dipeptidase (NAALADase), a membrane-bound peptidase, hydrolyzes α-NAAG, a major brain peptide, to N-acetylaspartate and glutamate. Discriminates between mGluR2 and mGluR3. mGluR3 activator. NMDA receptor antagonist. Neuroprotective. |
| | | Product Specific Literature References | N-acetylaspartylglutamate: an endogenous peptide with high affinity for a brain glutamate receptor: R. Zaczek, et al.; PNAS 80, 1116 (1983) Abstract
Characterization of the interactions of N-acetyl-aspartyl-glutamate with [3H]L-glutamate receptors: K.J. Koller & J.T. Coyle; Eur. J. Pharmacol. 98, 193 (1984) Abstract
The neurobiology of N-acetylaspartylglutamate: R.D. Blakely & J.T. Coyle; Int. Rev. Neurobiol. 30, 39 (1988) Abstract
Design, synthesis, and biological activity of a potent inhibitor of the neuropeptidase N-acetylated alpha-linked acidic dipeptidase: P.F. Jackson, et al.; J. Med. Chem. 39, 619 (1996) Abstract
The nagging question of the function of N-acetylaspartylglutamate: J.T. Coyle; Neurobiol. Dis. 4, 231 (1997) Abstract
N-acetylaspartylglutamate stimulates metabotropic glutamate receptor 3 to regulate expression of the GABA(A) alpha6 subunit in cerebellar granule cells: S. Ghose, et al.; J. Neurochem. 69, 2326 (1997) Abstract
N-acetylaspartylglutamate (NAAG) protects against rat striatal quinolinic acid lesions in vivo: L.R. Orlando, et al.; Neurosci. Lett. 236, 91 (1997) Abstract
N-acetylaspartylglutamate, N-acetylaspartate, and N-acetylated alpha-linked acidic dipeptidase in human brain and their alterations in Huntington and Alzheimer's diseases: L.A. Passani, et al.; Mol. Chem. Neuropathol. 31, 97 (1997) Abstract
Distribution of N-acetylaspartylglutamate immunoreactivity in human brain and its alteration in neurodegenerative disease: L.A. Passani, et al.; Brain Res. 772, 9 (1997) Abstract
N-acetylaspartylglutamate selectively activates mGluR3 receptors in transfected cells: B. Wroblewska, et al.; J. Neurochem. 69, 174 (1997) Abstract
Neuroprotective activity of N-acetylaspartylglutamate in cultured cortical cells: V. Bruno, et al.; Neuroscience 85, 751 (1998) Abstract
N-acetylaspartylglutamate activates cyclic AMP-coupled metabotropic glutamate receptors in cerebellar astrocytes: B. Wroblewska, et al.; Glia 24, 172 (1998) Abstract
A.P. Burlina, et al.; Eur. J. Pediatr. 158, 406 (1999) Abstract |
| | | | | RELATED PRODUCT GROUPS | Neurobiology > Excitatory Amino Acids & Receptors > NAALADase / Related Products / Peptides / Neurobiology > Excitatory Amino Acids & Receptors > Glutamate Receptors (Ionotropic) / Related Products > NMDA Receptors / Related Products | | | | | |
