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 ALX-151-026[ALEXIS] Revised 20-Jun-08  

N-Acetyl-Asp-Tyr(2-malonyl)-Val-Pro-Met-Leu-NH2

PRODUCT LINE   

Signal Transduction

PRODUCT FAMILIES   

Tyrosine Kinase Inhibitors

Ordering Information
 Product NumbersFormatSizeUnit PriceQuantity
 ALX-151-026-M001 1 mg  
Product Specification
FORMULA:   C39H57N7O14S
 
MW:   880.0
 
PURITY:   ≥96% (HPLC)
 
APPEARANCE:   White to off-white powder.
 
SOLUBILITY:   Soluble in water (1mg/ml).
 
SHIPPING:   AMBIENT
 
LONG TERM STORAGE:   -20°C
 
USE/STABILITY:   Peptide is very unstable.
Product Description

Peptide containing a phosphotyrosyl mimetic. Effective protein tyrosine kinase inhibitor. Inhibits the phosphoinositide 3-kinase (PI(3)K) C-terminal p85 SH2 domain.

Product Specific Literature References
L-O-(2-malonyl)tyrosine: a new phosphotyrosyl mimetic for the preparation of Src homology 2 domain inhibitory peptides: B. Ye, et al.; J. Med. Chem. 38, 4270 (1995) Abstract
RELATED PRODUCT GROUPS   

Peptides / Signal Transduction > PI(3)K-Akt-mTOR Pathway > Phosphoinositide 3-kinase [PI(3)K] / Related Products