Ampullosporin A |  | | PRODUCT LINE | Natural Products / Antibiotics | | | | PRODUCT FAMILIES | Antibiotics - Other Signal Transduction Pathway Modulators | | | | | Ordering Information | | | Product Numbers | Format | Size | Unit Price | Quantity | | | ALX-350-106-M001 |
|
1 mg | | | | | | |
| | | Product Specification | | |
| SEQUENCE: | Ac-Trp-Ala-Aib-Aib-Leu-Aib-Gln-Aib-Aib-Aib-Gln-Leu-Aib-Gln-Leucinol | | | | | |
| FORMULA: | C77H127N19O19 | | | | | |
| MW: | 1623.0 | | | | | |
| SOURCE/HOST: | Antibiotic isolated from Sepedonium ampullosporum. | | | | | |
| PURITY: | ≥98% (HPLC) | | | | | |
| SOLUBILITY: | Soluble in alcohols, chloroform or dichloromethane. Insoluble in water. | | | | | |
| SHIPPING: | AMBIENT | | | | | |
| LONG TERM STORAGE: | +4°C | | | | | |
| HAZARD: | TOXIC. | | | | | | Product Description | Peptaibol-type polypeptide. Induces pigment formation by the fungus Phoma destructiva, causes hypothermia in mice, displays neuroleptic activity in rats and forms instable pores in artificial bilayer membranes. |
| | | Product Specific Literature References | Ampullosporin, a new peptaibol-type antibiotic from Sepedonium ampullosporum HKI-0053 with neuroleptic activity in mice: M. Ritzau, et al.; J. Antibiot. 50, 722 (1997) Abstract
Differences in ion permeability of an artificial bilayer membrane caused by ampullosporin and bergofungin, new 15-membered peptaibol-type antibiotics: P. Grigoriev, et al.; Bioelectrochemistry 44, 155 (1997)
Differences in ion-channel formation by ampullosporins B, C, D and semisynthetic desacetyltryptophanyl ampullosporin A: P. Grigoriev, et al.; Bioelectrochemistry 57, 119 (2002) Abstract
Synthesis and biological evaluation of analogues of the peptaibol ampullosporin A: H.H. Nguyen, et al.; J. Med. Chem. 45, 2781 (2002) Abstract
Crystal structure and conformational analysis of ampullosporin A: M. Kronen, et al.; J. Pept. Sci. 9, 729 (2003) Abstract
Membrane association and activity of 15/16-membered peptide antibiotics: zervamicin IIB, ampullosporin A and antiamoebin I: T.N. Kropacheva, et al.; Biochim. Biophys. Acta 1715, 6 (2005) Abstract
Transcriptional response to the neuroleptic-like compound Ampullosporin A in the rat ketamine model: H. Krugel, et al.; J. Neurochem. 97, Suppl. 1, 74 (2006) Abstract |
| | | | | RELATED PRODUCT GROUPS | Neurobiology > Neurodegenerative Diseases > Alzheimer Research > Alzheimer Research Other Products / Signal Transduction > Ion Channels & Transporters / Related Products > Ion Channels & Transporters Other Products / Peptides | | | | | |
