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Protein Synthesis, Modification & Degradation |
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| ALX-270-244 | [ALEXIS] |
Revised 03-Apr-08 | | |
Caffeic acid phenylethyl ester | | | SYNONYMS | CAPE
Phenethyl caffeiate
Caffeic acid phenethyl ester | | | | PRODUCT LINE | Natural Products / Antibiotics | | | | PRODUCT FAMILIES | Natural Products - Anti-inflammatory Agents | | | | | Ordering Information | | | Product Numbers | Format | Size | Unit Price | Quantity | | | ALX-270-244-M010 |
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10 mg | | | | | ALX-270-244-M050 |
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50 mg | | | | |  | |
| | | Product Specification | | |
| FORMULA: | C17H16O4 | | | | | |
| MW: | 284.3 | | | | | |
| CAS NUMBER: | 115610-29-2 | | | | | |
| SOURCE/HOST: | Synthetic. | | | | | |
| PURITY: | ≥97% (HPLC) | | | | | |
| APPEARANCE: | White to off-white crystalline solid. | | | | | |
| SOLUBILITY: | Soluble in DMSO, 100% ethanol, methanol, acetone or acetonitrile; insoluble in water. | | | | | |
| SHIPPING: | AMBIENT | | | | | |
| LONG TERM STORAGE: | -20°C | | | | | |
| USE/STABILITY: | Stable for at least one year after receipt when stored at –20°C. | | | | | |
| HANDLING: | Protect from light and moisture. | | | | | |
| HAZARD: | IRRITANT. | | | | | | Product Description | Active component of propolis from honeybee hives, known to have anti-mitogenic, anti-carcinogenic, anti-inflammatory, and immunomodulatory properties. Potent and specific inhibitor of NF-κB activation, induced by TNF-α (Prod. No. ALX-522-008 (human) or Prod. No. ALX-522-009 (mouse)), PMA (Prod. No. ALX-445-004) and other inflammatory agents. Exhibits inhibitory activity against HIV-1 integrase (IC50=7µM). Suppresses lipid peroxidation and inhibits ornithine decarboxylase, protein tyrosine kinase and lipoxygenase activities. Induces apoptosis. |
| | | Product Specific Literature References | Hydroxylated aromatic inhibitors of HIV-1 integrase: T.R. Burke Jr., et al.; J. Med. Chem. 38, 4171 (1995) Abstract
Apoptosis and altered redox state induced by caffeic acid phenethyl ester (CAPE) in transformed rat fibroblast cells: C. Chiao, et al.; Cancer Res. 55, 3576 (1995) Abstract
Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B: K. Natarajan, et al.; PNAS 93, 9090 (1996) Abstract
Inhibitory effects of caffeic acid phenethyl ester on the activity and expression of cyclooxygenase-2 in human oral epithelial cells and in a rat model of inflammation: P. Michaluart, et al.; Cancer Res. 59, 2347 (1999) Abstract
Caffeic acid phenethyl ester induces leukocyte apoptosis, modulates nuclear factor-kappa B and suppresses acute inflammation: Z. Orban, et al.; Neuroimmunomodulation 7, 99 (2000) Abstract
Caffeic acid phenethyl ester inhibits T-cell activation by targeting both nuclear factor of activated T-cells and NF-kappaB transcription factors: N. Marquez, et al.; J. Pharmacol. Exp. Ther. 308, 993 (2004) Abstract
Caffeic acid derivatives: in vitro and in vivo anti-inflammatory properties: F.M. da Cunha, et al.; Free Radic. Res. 38, 1241 (2004) Abstract
Drastic effect of several caffeic acid derivatives on the induction of heme oxygenase-1 expression revealed by quantitative real-time RT-PCR: K. Suzuki, et al.; Biofactors 28, 151 (2006) Abstract |
| | | | Related Products | | | | Caffeic acid | | | | Caffeic acid ethyl ester | |
| | | | RELATED PRODUCT GROUPS | Natural Products / Antibiotics > Natural Products > Natural Products for Cancer Research > Natural Products - Chemopreventive Agents / Natural Products / Antibiotics > Natural Products > Natural Products - Signal Transduction Pathway Modulators > Natural Products - NF-kB Pathway Inhibitors / Signal Transduction > Kinases / Related Products > Tyrosine Kinases / Related Products > Tyrosine Kinase Inhibitors / Natural Products / Antibiotics > Natural Products > Natural Products - Signal Transduction Pathway Modulators > Natural Products - Protein Kinase Inhibitors / Natural Products / Antibiotics > Natural Products > Natural Products - Immunomodulators / Natural Products / Antibiotics > Natural Products > Natural Products - Anti-infective Agents > Natural Products - Antiviral / anti-HIV Agents / Natural Products / Antibiotics > Natural Products > Natural Products - Apoptosis Inducers & Inhibitors / Natural Products / Antibiotics > Natural Products > Polyphenols (Flavonoids, Stilbenoids, Phenolic Acids) > Phenolic Acids / Signal Transduction > NF-kB Pathway > NF-kB Pathway Inhibitors / Viral Signalling > HIV / AIDS / Related Products | | | | | |
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