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ALX-270-385 [ALEXIS] Revised 07-Jan-09
Aloisine A SYNONYMS    RP107 7-n-Butyl-6-(4-hydroxyphenyl)[5H]pyrrolo[2,3-b]pyrazine PRODUCT LINE    Cell Cycle PRODUCT FAMILIES    CDK & Cyclin Inhibitors Ordering Information  Product Numbers Format Size Unit Price Quantity  ALX-270-385-M001 1 mg     Product Specification FORMULA:    C16H17N3O   MW:    267.3   CAS NUMBER:    496864-16-5   PURITY:    ≥95% (HPLC)   APPEARANCE:    Yellow solid.   SOLUBILITY:    10mg/ml soluble in DMSO.   SHIPPING:    AMBIENT   LONG TERM STORAGE:    -20°C   HANDLING:    Packaged under inert gas. Protect from light. Product Description Cell permeable, potent, selective, reversible and ATP-competitive inhibitor of CDK1/cyclin B (IC50=150nM), CDK2/cyclin A (IC50=120nM), CDK2/cyclin E (IC50=400nM), CDK5/p25 (IC50=200nM), CDK5/p35 (IC50=160nM) and GSK-3α (IC50=500nM). Also inhibits GSK-3β (IC50=650nM) and c-Jun N-terminal kinase (JNK) (IC50~3-10µM). Poor inhibitor of CK1, CK2, CDK4/cyclin D1, MAPKK, PKA, PKG, PKCs and c-raf (IC50≥100µM). Blocks cell cycle in both G1 and G2 phase. Product Specific Literature References Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects: Y. Mettey, et al.; J. Med. Chem. 46, 222 (2003) Abstract RELATED PRODUCT GROUPS    Signal Transduction > Wnt Signalling Pathway / Related Products > Glycogen Synthase Kinase-3 [GSK-3] / Related Products > GSK-3 Inhibitors / Signal Transduction > MAP Kinase Pathways > JNK [SAPK1] / Related Products / Cell Cycle > Cell Cycle Blockers & Inhibitors / Related Products