AMI-1 |
 |
| SYNONYMS | Arginine N-Methyltransferase Inhibitor-1 |
|
|
| PRODUCT LINE | Nitric Oxide Pathway |
|
|
| PRODUCT FAMILIES | PRMTs, Mono- & Dimethylarginine / Related Products |
|
|
|
| Ordering Information |
|
| Product Numbers | Format | Size | Unit Price | Quantity | | | ALX-270-440-M005 |
|
5 mg | | | | | ALX-270-440-M025 |
|
25 mg | | | | | | |
|
|
| Product Specification |
|
|
| FORMULA: | C21H12N2O9S2Na4 |
|
|
| |
|
| MW: | 592.4 |
|
|
| |
|
| PURITY: | ≥98% (1H-NMR and HPLC) |
|
|
| |
|
| APPEARANCE: | Brown solid. |
|
|
| |
|
| SOLUBILITY: | Soluble in water, 100% ethanol or DMSO. |
|
|
| |
|
| SHIPPING: | SHIPPED ON BLUE ICE |
|
|
| |
|
| LONG TERM STORAGE: | -20°C |
|
|
| |
|
| HANDLING: | Hygroscopic. Protect from light. After reconstitution, prepare aliquots and store at -20°C. |
|
|
|
|
| Product Description |
Potent, cell permeable and specific inhibitor of protein arginine N-methyltransferases (PRMTs) (IC50=8.8µM for human PRMT1 and 3.0µM for yeast Hmt1p). Does not compete for the AdoMet (S-adenosyl-L-methionine; SAM) binding site. Exhibits only minimal effects on lysine N-methyltransferases. Suppresses the transcriptional coactivator activity of PRMT1 and PRMT4. Inhibitor of HIV-1 RT polymerase (IC50=5.0µM). |
|
| | Product Specific Literature References | A novel mechanism for inhibition of HIV-1 reverse transcriptase: A.G. Skillman, et al.; Bioorg. Chem. 30, 443 (2002) Abstract
Small molecule regulators of protein arginine methyltransferases: D. Cheng, et al.; J. Biol. Chem. 279, 23892 (2004) Full Text; http://www.jbc.org/cgi/content/full/279/23/23892 |
|
|
|
|
| RELATED PRODUCT GROUPS |
Viral Signalling > HIV / AIDS / Related Products |
|
|
|
