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ALX-380-051 [ALEXIS] Revised 20-Jun-08
Anisomycin SYNONYMS    2-(p-Methoxybenzyl)-3,4-pyrrolidinediol-3-acetate PRODUCT LINE    Natural Products / Antibiotics PRODUCT FAMILIES    Antibiotics - Other Signal Transduction Pathway Modulators Ordering Information  Product Numbers Format Size Unit Price Quantity  ALX-380-051-M010 10 mg      ALX-380-051-M050 50 mg      ALX-380-051-M100 100 mg     Product Specification FORMULA:    C14H19NO4   MW:    265.3   CAS NUMBER:    22862-76-6   MERCK INDEX:    14: 670   RTECS:    BZ9800000   SOURCE/HOST:    Isolated from Streptomyces griseolus.   PURITY:    ≥98% (HPLC)   APPEARANCE:    White crystalline solid.   SOLUBILITY:    Soluble in DMSO (25mg/ml), 100% ethanol, methanol or ethyl acetate (10mg/ml).   SHIPPING:    AMBIENT   LONG TERM STORAGE:    -20°C   HAZARD:    TOXIC. Product Description Antibiotic. Activator of p38 and MAP kinases. Synergistic with growth factors and phorbol esters to superinduce cFos and cJun, by acting as a potent signalling agonist. Induces apoptosis in the human monoblastoid cell line. Used in the eradication of bean mildew. Inhibits other pathogenic fungi in plants. Product Specific Literature References Anisomycin, a new anti-protozoan antibiotic: B. A. Sobin & F. W. Tanner; J. Am. Chem. Soc. 76, 4053 (1954) DNA fragmentation and cytolysis in U937 cells treated with diphtheria toxin or other inhibitors of protein synthesis: S.K. Kochi & R.J. Collier; Exp. Cell. Res. 208, 296 (1993) Abstract The stress-activated protein kinase subfamily of c-Jun kinases: J.M. Kyriakis, et al.; Nature 369, 156 (1994) Abstract Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun: I. Sanchez, et al.; Nature 372, 794 (1994) Abstract Anisomycin and rapamycin define an area upstream of p70/85S6k containing a bifurcation to histone H3-HMG-like protein phosphorylation and c-fos-c-jun induction: E. Kardalinou, et al.; Mol. Cell. Biol. 14, 1066 (1994) Abstract Protein synthesis inhibitor phase shifts vasopressin rhythms in long- term suprachiasmatic cultures: K. Shinohara & T. Oka; NeuroReport 5, 2201 (1994) Abstract Anisomycin selectively desensitizes signalling components involved in stress kinase activation and fos and jun induction: C.A. Hazzalin, et al.; Mol Cell Biol 18, 1844 (1998) Abstract Anisomycin treatment paradigm affects duration of long-term potentiation in slices of the amygdala: P. Okulski, et al.; Neuroscience 114, 1 (2002) Abstract Downregulation of Ski and SnoN co-repressors by anisomycin: A. Vazquez-Macias, et al.; FEBS Lett. 579, 3701 (2005) Abstract Anisomycin and the reconsolidation hypothesis: J.W. Rudy, et al.; Learn. Mem. 13, 1 (2006), Review Abstract A chemical screen identifies anisomycin as an anoikis sensitizer that functions by decreasing FLIP protein synthesis: I.A. Mawji, et al.; Cancer Res. 67, 8307 (2007) Abstract Anisomycin abrogates repression of protooncogene c-fos transcription in E1A + cHa-ras-transformed cells through activation of MEK/ERK kinase cascade: A. N. Kukushkin, et al.; J. Cell. Biochem. 103, 1005 (2008) Abstract RELATED PRODUCT GROUPS    Signal Transduction > MAP Kinase Pathways > MAPK Pathway Activators / Signal Transduction > MAP Kinase Pathways > JNK [SAPK1] / Related Products / Natural Products / Antibiotics > Antibiotics > Antibiotics - Apoptosis Inducers & Inhibitors