5-Aminosalicylic acid |
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| SYNONYMS | 5-ASA
Mesalamine
5-Amino-2-hydroxybenzoic acid |
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| PRODUCT LINE | Signal Transduction |
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| PRODUCT FAMILIES | NF-kB Pathway Inhibitors |
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| Ordering Information |
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| Product Numbers | Format | Size | Unit Price | Quantity | | | ALX-430-110-G005 |
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5 g | | | | | | |
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| Product Specification |
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| FORMULA: | C7H7NO3 |
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| MW: | 153.1 |
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| CAS NUMBER: | 89-57-6 |
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| MERCK INDEX: | 14: 5904 |
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| PURITY: | ≥98% |
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| SOLUBILITY: | Soluble in 1 M hydrochloric acid. |
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| SHIPPING: | AMBIENT |
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| LONG TERM STORAGE: | +4°C |
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| Product Description |
Inhibits TNF-α regulated IκB degradation and NF-κB activation. |
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| | Product Specific Literature References | Inhibition of nuclear factor kappa B and induction of apoptosis in T-lymphocytes by sulfasalazine: S. Liptay, et al.; Br. J. Pharmacol. 128, 1361 (1999) Abstract
Aminosalicylic acid inhibits IkappaB kinase alpha phosphorylation of IkappaBalpha in mouse intestinal epithelial cells: F. Yan & D.B. Polk; J. Biol. Chem. 274, 36631 (1999) Full Text; http://www.jbc.org/cgi/reprint/274/51/36631 |
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| RELATED PRODUCT GROUPS |
Inflammation > Anti-inflammatory Agents > Non-Steroidal Anti-Inflammatory Drugs [NSAIDS] |
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