Ac-DEVD-pNA |
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| SYNONYMS | Caspase-3 Substrate (Chromogenic) |
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| PRODUCT LINE | Cell Death / Apoptosis / Autophagy |
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| PRODUCT FAMILIES | Caspase Substrates |
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| Ordering Information |
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| Product Numbers | Format | Size | Unit Price | Quantity | | | ALX-260-033-M001 |
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1 mg | | | | | ALX-260-033-M005 |
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5 mg | | | | | | |
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| Product Specification |
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| SEQUENCE: | Ac-Asp-Glu-Val-Asp-pNA (pNA = p-Nitroaniline) |
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| FORMULA: | C26H34N6O13 |
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| MW: | 638.6 |
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| PEPTIDE CONTENT: | 70-95% |
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| PURITY: | ≥97% (HPLC) |
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| APPEARANCE: | White to off-white powder. |
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| FORMULATION: | Lyophilized. |
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| SOLUBILITY: | Soluble in DMSO or buffer, pH 7. |
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| SHIPPING: | AMBIENT |
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| LONG TERM STORAGE: | -20°C |
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| USE/STABILITY: | Always use fresh solutions. |
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| HANDLING: | Keep cool and dry. |
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| Product Description |
Chromogenic substrate for caspase-3. Also a substrate for caspase-1, -4 and -7. |
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| | Product Specific Literature References | Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis: D.W. Nicholson, et al.; Nature 376, 37 (1995) Abstract
Activation of the CPP32 protease in apoptosis induced by 1-beta-D- arabinofuranosylcytosine and other DNA-damaging agents: R. Datta, et al.; Blood 88, 1936 (1996) Abstract
Substrate specificities of caspase family proteases: R.V. Talanian, et al.; J. Biol. Chem. 272, 9677 (1997) Full Text; http://www.jbc.org/cgi/reprint/272/15/9677.pdf |
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| | General Information | |
Background/Technical Information | | λmax of pNA is 400nm. | | |
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| RELATED PRODUCT GROUPS |
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