Ac-IETD-AMC |
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| SYNONYMS | Caspase-8 Substrate (Fluorogenic)
Granzyme B Substrate (Fluorogenic) |
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| PRODUCT LINE | Cell Death / Apoptosis / Autophagy |
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| PRODUCT FAMILIES | Caspase Substrates |
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| Ordering Information |
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| Product Numbers | Format | Size | Unit Price | Quantity | | | ALX-260-042-M001 |
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1 mg | | | | | ALX-260-042-M005 |
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5 mg | | | | | | |
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| Product Specification |
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| SEQUENCE: | Ac-Ile-Glu-Thr-Asp-AMC (AMC=7-Amino-4-methylcoumarin) |
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| FORMULA: | C31H41N5O12 |
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| MW: | 675.7 |
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| PEPTIDE CONTENT: | 70-90% |
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| PURITY: | ≥98% (HPLC) |
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| FORMULATION: | Lyophilized. |
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| SOLUBILITY: | Soluble in DMSO. Dilute with buffer, pH 7.5. |
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| SHIPPING: | AMBIENT |
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| LONG TERM STORAGE: | -20°C |
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| Product Description |
Fluorogenic substrate for caspase-8 and granzyme B. Also a substrate for caspase-10. |
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| | Product Specific Literature References | | Bid truncation, bid/bax targeting to the mitochondria, and caspase activation associated with neutrophil apoptosis are inhibited by granulocyte colony-stimulating factor: N.A. Maianski, et al.; J. Immunol. 172, 7024 (2004) Abstract |
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| | General Information | |
Background/Technical Information | | AMC has an excitation maximum of 380nm and an emission maximum of 460nm. | | |
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| RELATED PRODUCT GROUPS |
Cell Death / Apoptosis / Autophagy > Granzymes / Related Products > Granzyme Substrates |
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