Ac-IETD-pNA |
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| SYNONYMS | Caspase-8 Substrate (Chromogenic)
Granzyme B Substrate (Chromogenic) |
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| PRODUCT LINE | Cell Death / Apoptosis / Autophagy |
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| PRODUCT FAMILIES | Caspase Substrates |
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| Ordering Information |
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| Product Numbers | Format | Size | Unit Price | Quantity | | | ALX-260-045-M001 |
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1 mg | | | | | ALX-260-045-M005 |
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5 mg | | | | | | |
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| Product Specification |
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| SEQUENCE: | Ac-Ile-Glu-Thr-Asp-pNA (pNA=p-Nitroaniline) |
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| FORMULA: | C27H38N6O12 |
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| MW: | 638.6 |
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| PEPTIDE CONTENT: | 70-90% |
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| PURITY: | 98% (HPLC) |
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| APPEARANCE: | White to yellow powder. |
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| FORMULATION: | Lyophilized. |
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| SOLUBILITY: | Soluble in DMSO. Dilute with buffer, pH 7.0-7.5. |
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| SHIPPING: | AMBIENT |
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| LONG TERM STORAGE: | -20°C |
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| HANDLING: | Keep cool and dry. |
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| Product Description |
Chromogenic substrate for caspase-8 and granzyme B. Also a substrate for caspase-10. |
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| | Product Specific Literature References | A sequential two-step mechanism for the production of the mature p17:p12 form of caspase-3 in vitro: Z. Han, et al.; J. Biol. Chem. 272, 13432 (1997) Full Text; http://www.jbc.org/cgi/reprint/272/20/13432.pdf
Apicidin, a histone deacetylase inhibitor, induces apoptosis and Fas/Fas ligand expression in human acute promyelocytic leukemia cells: S.H. Kwon, et al.; J. Biol. Chem. 277, 2073 (2002) Full Text; http://www.jbc.org/cgi/reprint/277/3/2073.pdf
Apoptosome-independent pathway for apoptosis. Biochemical analysis of APAF-1 defects and biological outcomes: C.A. Belmokhtar, et al.; J. Biol. Chem. 278, 29571 (2003) Full Text; http://www.jbc.org/cgi/content/full/278/32/29571 |
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| | General Information | |
Background/Technical Information | | λmax of pNA is 400nm. | | |
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| RELATED PRODUCT GROUPS |
Cell Death / Apoptosis / Autophagy > Granzymes / Related Products > Granzyme Substrates |
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