Ac-AAVALLPAVLLALLAPDEVD-CHO |
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| SYNONYMS | Caspase-3 Inhibitor (Aldehyde) |
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| PRODUCT LINE | Cell Death / Apoptosis / Autophagy |
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| PRODUCT FAMILIES | Caspase Inhibitors |
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| Ordering Information |
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| Product Numbers | Format | Size | Unit Price | Quantity | | | ALX-260-046-M001 |
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1 mg | | | | | ALX-260-046-M005 |
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5 mg | | | | | | |
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| Product Specification |
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| SEQUENCE: | Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Asp-Glu-Val-Asp-CHO |
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| FORMULA: | C94H158N20O27 |
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| MW: | 2000.4 |
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| PEPTIDE CONTENT: | 65-95%. |
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| PURITY: | ≥95% (HPLC) |
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| APPEARANCE: | White to off-white powder. |
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| FORMULATION: | Lyophilized. TFA salt. |
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| SOLUBILITY: | Soluble in DMSO. |
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| SHIPPING: | AMBIENT |
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| LONG TERM STORAGE: | -20°C |
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| HANDLING: | Keep cool and dry. After dissolving, prepare aliquots and store at -20°C |
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| Product Description |
Reversible, cell permeable inhibitor of caspase-3. Also inhibits caspase-6, -7, -8 and -10. |
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| | Product Specific Literature References | Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis: W. Nicholson, et al.; Nature 376, 37 (1995) Abstract
Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase: M. Tewari, et al.; Cell 81, 801 (1995) Abstract
Activation of CPP32-like proteases is not sufficient to trigger apoptosis: inhibition of apoptosis by agents that suppress activation of AP24, but not CPP32-like activity: S.C. Wright, et al.; J. Exp. Med. 186, 1107 (1997) Abstract |
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| RELATED PRODUCT GROUPS |
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