Ac-ESMD-CHO |
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| SYNONYMS | Caspase-8 Inhibitor (Aldehyde)
Granzyme B Inhibitor (Aldehyde) |
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| PRODUCT LINE | Cell Death / Apoptosis / Autophagy |
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| PRODUCT FAMILIES | Caspase Inhibitors |
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| Ordering Information |
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| Product Numbers | Format | Size | Unit Price | Quantity | | | ALX-260-056-M001 |
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1 mg | | | | | ALX-260-056-M005 |
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5 mg | | | | | | |
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| Product Specification |
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| SEQUENCE: | Ac-Glu-Ser-Met-Asp-CHO |
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| FORMULA: | C19H30N4O10S |
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| MW: | 506.5 |
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| PEPTIDE CONTENT: | 70-90%. |
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| PURITY: | ≥99% (HPLC) |
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| APPEARANCE: | White powder. |
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| FORMULATION: | Lyophilized. |
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| SOLUBILITY: | Soluble in distilled water. |
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| SHIPPING: | AMBIENT |
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| LONG TERM STORAGE: | -20°C |
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| USE/STABILITY: | Use always fresh solutions. |
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| HANDLING: | Keep cool and dry. Keep under inert gas. |
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| Product Description |
Reversible inhibitor of caspase-8 and granzyme B. Also inhibits caspase-6 and -10. The peptide sequence corresponds to one of the cleavage sites of the inactive 32kDa caspase-3 precursor (aa 25-28). It blocks the formation of the p17 subunit and concomitantly induces the accumulation of the p20 peptide. |
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| | Product Specific Literature References | | A sequential two-step mechanism for the production of the mature p17:p12 form of caspase-3 in vitro: Z. Han, et al.; J. Biol. Chem. 272, 13432 (1997) Full Text; http://www.jbc.org/cgi/reprint/272/20/13432.pdf |
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| RELATED PRODUCT GROUPS |
Cell Death / Apoptosis / Autophagy > Granzymes / Related Products > Granzyme Inhibitors |
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