Ac-IETD-AFC |
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| SYNONYMS | Caspase-8 Substrate (Fluorogenic)
Granzyme B Substrate (Fluorogenic) |
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| PRODUCT LINE | Cell Death / Apoptosis / Autophagy |
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| PRODUCT FAMILIES | Caspase Substrates |
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| Ordering Information |
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| Product Numbers | Format | Size | Unit Price | Quantity | | | ALX-260-110-M005 |
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5 mg | | | | | ALX-260-110-M010 |
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10 mg | | | | | | |
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| Product Specification |
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| SEQUENCE: | Ac-Ile-Glu-Thr-Asp-AFC (AFC=7-Amino-4-trifluoromethylcoumarin) |
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| FORMULA: | C31H38F3N5O12 |
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| MW: | 729.7 |
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| PURITY: | ≥98% (HPLC) |
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| APPEARANCE: | White to off-white powder. |
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| SOLUBILITY: | Soluble in DMSO. |
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| SHIPPING: | AMBIENT |
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| LONG TERM STORAGE: | -20°C |
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| HANDLING: | Keep cool and dry. |
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| Product Description |
Fluorogenic substrate for caspase-8/caspase-3 processing enzyme and granzyme B. Also a substrate for caspase-10. |
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| | Product Specific Literature References | | Rapid cytochrome c release, activation of caspases 3, 6, 7 and 8 followed by Bap31 cleavage in HeLa cells treated with photodynamic therapy: D.J. Granville, et al.; FEBS Lett. 437, 5 (1998) Abstract |
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| | General Information | |
Background/Technical Information | | AFC has an excitation maximum of 400nm and an emission maximum of 505nm. | | |
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| RELATED PRODUCT GROUPS |
Cell Death / Apoptosis / Autophagy > Granzymes / Related Products > Granzyme Substrates |
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