Signal Transduction



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 ALX-260-152[ALEXIS] Revised 25-Nov-08  

Ac-IEPD-pNA

SYNONYMS   

Caspase-8 Substrate (Chromogenic)
Granzyme B Substrate (Chromogenic)

PRODUCT LINE   

Cell Death / Apoptosis / Autophagy

PRODUCT FAMILIES   

Caspase Substrates

Ordering Information
 Product NumbersFormatSizeUnit PriceQuantity
 ALX-260-152-M001 1 mg  
 ALX-260-152-M005 5 mg  
Product Specification
SEQUENCE:   Ac-Ile-Glu-Pro-Asp-pNA (pNA=p-Nitroaniline)
 
FORMULA:   C28H38N6O11
 
MW:   634.6
 
PURITY:   ≥98% (HPLC)
 
APPEARANCE:   White to off-white powder.
 
SOLUBILITY:   Soluble in DMSO or in a basic buffer of pH 7.5.
 
SHIPPING:   AMBIENT
 
LONG TERM STORAGE:   -20°C
Product Description

Chromogenic substrate for caspase-8 and granzyme B.

Product Specific Literature References
Definition and redesign of the extended substrate specificity of granzyme B: J.L. Harris, et al.; J. Biol. Chem. 273, 27364 (1998) Full Text; http://www.jbc.org/cgi/reprint/273/42/27364
General Information

Background/Technical Information   
λmax of pNA is 400nm.
RELATED PRODUCT GROUPS   

Cell Death / Apoptosis / Autophagy > Granzymes / Related Products > Granzyme Substrates