Aaptamine |
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| SYNONYMS | 8,9-Dimethoxy-1H-benzo[de][1,6]naphtyridine |
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| PRODUCT LINE | Natural Products / Antibiotics |
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| PRODUCT FAMILIES | Other Toxins |
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| Ordering Information |
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| Product Numbers | Format | Size | Unit Price | Quantity | | | ALX-350-104-M001 |
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1 mg | | | | | | |
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| Product Specification |
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| FORMULA: | C13H12N2O2 |
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| MW: | 228.3 |
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| CAS NUMBER: | 85547-22-4 |
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| SOURCE/HOST: | Isolated from the sponge Aaptos aaptos. |
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| PURITY: | ≥97% |
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| APPEARANCE: | Oil. |
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| SOLUBILITY: | Soluble in DMSO or 100% ethanol. |
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| SHIPPING: | AMBIENT |
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| LONG TERM STORAGE: | -20°C |
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| HANDLING: | Protect from light. |
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| HAZARD: | TOXIC. |
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| Product Description |
Competitive antagonist of α-adrenoceptors in vascular smooth muscle cells. Inhibits cancer cell growth. |
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| | Product Specific Literature References | Alpha-adrenoceptor blocking action of aaptamine, a novel marine natural product, in vascular smooth muscle: Y. Ohizumi, et al.; J. Pharm. Pharmacol. 36, 785 (1984) Abstract
Antineoplastic agents 491. Synthetic conversion of aaptamine to isoaaptamine, 9-demethylaaptamine, and 4-methylaaptamine: G.R. Pettit, et al.; J. Org. Chem. 69, 2251 (2004) Abstract
Aaptamine, a spongean alkaloid, activates p21 promoter in a p53-independent manner: S. Aoki, et al.; BBRC 342, 101 (2006) Abstract |
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| RELATED PRODUCT GROUPS |
Cancer > Antitumor Reagents > Antitumor Agents (Anti-proliferative) / Neurobiology > Monoamine Neurotransmitters & Receptors > Adrenergics & Adrenergic Receptors / Related Products / Natural Products / Antibiotics > Natural Products > Natural Products for Cancer Research > Natural Products - Antitumor Reagents / Natural Products / Antibiotics > Natural Products > Marine Natural Products / Natural Products / Antibiotics > Natural Products > Alkaloids |
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