7BIO |
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| SYNONYMS | (2’Z, 3’E)-7-Bromoindirubin-3’-monoxime
MLS2156 |
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| PRODUCT LINE | Cell Death / Apoptosis / Autophagy |
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| PRODUCT FAMILIES | Non-apoptotic Cell Death / Necrosis |
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| Ordering Information |
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| Product Numbers | Format | Size | Unit Price | Quantity | | | ALX-430-149-M005 |
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5 mg | | | | | ALX-430-149-M025 |
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25 mg | | | | |  | |
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| Product Specification |
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| FORMULA: | C16H10BrN3O2 |
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| MW: | 356.2 |
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| PURITY: | ≥95% (1H-NMR) |
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| APPEARANCE: | Dark brown solid. |
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| SOLUBILITY: | Soluble in DMSO. |
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| SHIPPING: | AMBIENT |
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| LONG TERM STORAGE: | -20°C |
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| HANDLING: | Protect from light. |
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| HAZARD: | IRRITANT. |
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| Product Description |
Induces a rapid caspase-independent cell death process distinct from apoptosis. Demonstrated selective inhibition of aurora kinase B (IC50=4.6µM) and aurora kinase C (IC50=0.7µM) whereas the homologeous aurora kinase A is poorly inhibited. |
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| | Product Specific Literature References | 3’-Substituted 7-halogenoindirubins, a new class of cell death inducing agents: Y. Ferandin, et al.; J. Med. Chem. 49, 4638 (2006) Abstract
7-Bromoindirubin-3’-oxime induces caspase-independent cell death: J. Ribas, et al.; Oncogene 25, 6304 (2006) Abstract
An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted indirubins: V. Myrianthopoulos, et al.; J. Med. Chem. 50, 4027 (2007) Abstract
7-Bromoindirubin-3’-oxime uncovers a serine protease-mediated paradigm of necrotic cell death: J. Ribas, et al.; Biochem. Pharmacol. 76, 39 (2008) Abstract |
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| Related Products |
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| | Indirubin-3'-monoxime | | | | Me-7BIO | | | | 6BIO | | | | Indirubin-5-sulfonic acid . sodium salt | | | | Indirubin | | | | 5-Iodo-indirubin-3'-monoxime | |
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| RELATED PRODUCT GROUPS |
Cell Cycle > Kinases in Cell Cycle Regulation > Aurora / Related Products |
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