A23187 (free acid) |
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| SYNONYMS | Calcium Ionophore A23187
Calcimycin
Antibiotic A23187 |
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| PRODUCT LINE | Natural Products / Antibiotics |
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| PRODUCT FAMILIES | Antibiotics - Ionophores |
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| Ordering Information |
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| Product Numbers | Format | Size | Unit Price | Quantity | | | ALX-450-001-M001 |
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1 mg | | | | | ALX-450-001-M005 |
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5 mg | | | | | ALX-450-001-5001 |
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5x1 mg | | | | | ALX-450-001-M010 |
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10 mg | | | | | ALX-450-001-M025 |
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25 mg | | | | | ALX-450-001-M050 |
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50 mg | | | | | | |
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| Product Specification |
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| FORMULA: | C29H37N3O6 |
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| MW: | 523.6 |
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| CAS NUMBER: | 52665-69-7 |
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| MERCK INDEX: | 14: 1639 |
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| RTECS: | DM4676000 |
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| SOURCE/HOST: | Isolated from Streptomyces chartreusis. |
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| PURITY: | ≥98% (HPLC) |
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| APPEARANCE: | White to off-white solid. |
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| SOLUBILITY: | Soluble in DMSO, 100% ethanol or methylene chloride; slightly soluble in water. Solubilize in DMSO or ethanol prior to preparing aqueous solutions of very low concentrations. |
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| SHIPPING: | AMBIENT |
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| LONG TERM STORAGE: | +4°C |
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| USE/STABILITY: | In aqueous systems product may aggregate over time. |
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| HANDLING: | Protect from light. In aqueous systems, the product aggregates over time. |
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| HAZARD: | IRRITANT. |
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| Product Description |
Antibiotic possessing weak in vitro antimicrobial activity against gram positive bacteria and fungi. Divalent cation ionophore commonly used to increase intracellular Ca2+ levels in intact cells. |
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| | Product Specific Literature References | A23187: a divalent cation ionophore: P. W. Reed & H. A. Lardy; J. Biol. Chem. 247, 6970 (1972) Abstract
Effects of antibiotic ionophore, A23187, on oxidative phosphorylation and calcium transport of liver mitochondria: D.T. Wong, et al.; Arch. Biochem. Biophys. 156, 578 (1973) Abstract
Biological applications of ionophores: B.C. Pressman; Annu. Rev. Biochem. 45, 501 (1976), (Review) Abstract
Molecular mechanisms of endothelium-mediated vasodilation: R.R. Fiscus; Semin. Thromb. Hemost. 14 Suppl, 12 (1988), (Review) Abstract
Calcium ionophore A23187 action on cardiac myocytes is accompanied by enhanced production of reactive oxygen species: 1740, 481 (2005): T. Przygodzki, et al.; Biochim. Biophys. Acta 1740, 481 (2005) Abstract |
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| | General Information | |
Background/Technical Information | | Note: Due to the product’s strong inherent fluorescence, different crystal forms might influence the color. | | |
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| RELATED PRODUCT GROUPS |
Nitric Oxide Pathway > Nitric Oxide Pathway Other Products / Oxidative Stress > Respiratory Chain / Related Products > Respiratory Chain Other Products / Natural Products / Antibiotics > Antibiotics > Antibiotics - Signal Transduction Pathway Modulators > Antibiotics - ATPase Inhibitors |
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