AS601245 |
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| SYNONYMS | 1,3-Benzothiazol-2-yl-(2-{[2-(3-pyridinyl)ethyl]amino}-4-pyrimidinyl) acetonitrile
JNK Inhibitor V |
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| PRODUCT LINE | Signal Transduction |
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| PRODUCT FAMILIES | JNK [SAPK1] / Related Products |
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| Ordering Information |
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| Product Numbers | Format | Size | Unit Price | Quantity | | | ALX-270-443-M001 |
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1 mg | | | | | ALX-270-443-M005 |
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5 mg | | | | | ALX-270-443-M025 |
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25 mg | | | | | | |
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| Product Specification |
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| FORMULA: | C20H16N6S |
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| MW: | 372.5 |
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| CAS NUMBER: | 345987-15-7 |
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| PURITY: | ≥95% (HPLC) |
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| APPEARANCE: | White to yellow solid. |
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| PURITY DETAIL: | Sum of two isomers. |
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| SOLUBILITY: | Soluble in DMSO (10mg/ml). |
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| SHIPPING: | AMBIENT |
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| LONG TERM STORAGE: | -20°C |
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| USE/STABILITY: | Stock solutions are stable for up to 3 months when stored at -20°C. |
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| HANDLING: | Hygroscopic. Packaged under inert gas. Protect from light. |
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| HAZARD: | HARMFUL. |
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| IDENTITY: | Identity determined by 1H-NMR. |
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| Product Description |
Potent and cell permeable ATP competitive JNK inhibitor (hJNK1: IC50=150nM, hJNK2: IC50=220nM and hJNK3: IC50=70 nM). Displays anti-inflammatory properties and has been shown to reduce TNF-α plasma levels induced by LPS in mice. |
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| | Product Specific Literature References | AS601245 (1,3-benzothiazol-2-yl (2-[[2-(3-pyridinyl) ethyl] amino]-4 pyrimidinyl) acetonitrile): a c-Jun NH2-terminal protein kinase inhibitor with neuroprotective properties: S. Carboni, et al.; J. Pharmacol. Exp. Ther. 310, 25 (2004) Full Text; http://jpet.aspetjournals.org/cgi/reprint/310/1/25
Design and synthesis of the first generation of novel potent, selective, and in vivo active (benzothiazol-2-yl)acetonitrile inhibitors of the c-Jun N-terminal kinase: P. Gaillard, et al.; J. Med. Chem. 48, 4596 (2005) Abstract |
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| RELATED PRODUCT GROUPS |
Chemokines & Cytokines > TNF & TNF Receptor Superfamily / Related Products > TNF-alpha & TNF Receptors / Related Products > TNF-alpha & TNF Receptors Other Products / Inflammation > Anti-inflammatory Agents > Anti-inflammatory Agents Other Products |
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