AS-604850 |
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| SYNONYMS | 5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione |
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| PRODUCT LINE | Signal Transduction |
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| PRODUCT FAMILIES | Phosphoinositide 3-kinase [PI(3)K] / Related Products |
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| Ordering Information |
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| Product Numbers | Format | Size | Unit Price | Quantity | | | ALX-270-461-M001 |
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1 mg | | | | | ALX-270-461-M005 |
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5 mg | | | | | ALX-270-461-M025 |
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25 mg | | | | | | |
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| Product Specification |
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| FORMULA: | C11H5F2NO4S |
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| MW: | 285.2 |
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| PURITY: | ≥98% (HPLC) |
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| APPEARANCE: | Off-white to yellow solid. |
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| SOLUBILITY: | Soluble in acetonitrile (6mg/ml), DMSO (50mg/ml), methanol (9mg/ml) or 100% ethanol. |
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| SHIPPING: | AMBIENT |
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| LONG TERM STORAGE: | -20°C |
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| HANDLING: | Protect from light. |
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| HAZARD: | IRRITANT. |
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| MELTINGPOINT: | 200-202°C |
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| Product Description |
Potent, cell permeable and ATP-competitive inhibitor of phosphoinositide 3-kinase γ (PI(3)Kγ). Exhibits selectivity over other PI(3)K isoforms. |
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| | Product Specific Literature References | Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis: M. Camps, et al.; Nat. Med. 11, 936 (2005) Abstract
Key role of the p110delta isoform of PI3K in B-cell antigen and IL-4 receptor signaling: comparative analysis of genetic and pharmacologic interference with p110delta function in B cells: A. Bilancio, et al.; Blood 107, 642 (2006) Full Text; http://www.bloodjournal.org/cgi/reprint/107/2/642 |
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