AS-605240 |
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| SYNONYMS | 5-Quinoxalin-6-ylmethylene-thiazolidine-2,4-dione |
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| PRODUCT LINE | Signal Transduction |
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| PRODUCT FAMILIES | Phosphoinositide 3-kinase [PI(3)K] / Related Products |
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| Ordering Information |
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| Product Numbers | Format | Size | Unit Price | Quantity | | | ALX-270-462-M001 |
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1 mg | | | | | ALX-270-462-M005 |
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5 mg | | | | | ALX-270-462-M025 |
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25 mg | | | | | | |
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| Product Specification |
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| FORMULA: | C12H7N3O2S |
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| MW: | 257.3 |
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| PURITY: | ≥95% (1H-NMR) |
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| APPEARANCE: | Pink to reddish brown solid. |
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| SOLUBILITY: | Soluble in DMSO. |
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| SHIPPING: | AMBIENT |
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| LONG TERM STORAGE: | -20°C |
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| HANDLING: | Packaged under inert gas. Protect from light. |
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| Product Description |
Potent, cell permeable and ATP-competitive inhibitor of phosphoinositide 3-kinase γ (PI(3)Kγ). Exhibits selectivity over other PI(3)K isoforms. |
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| | Product Specific Literature References | Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis: M. Camps, et al.; Nat. Med. 11, 936 (2005) Abstract
PI3Kgamma inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus: D.F. Barber, et al.; Nat. Med. 11, 933 (2005) Abstract |
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