AS-252424 |
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| SYNONYMS | 5-[5-(4-Fluoro-2-hydroxyphenyl)-furan-2-ylmethylene)]-thiazolidine-2,4-dione |
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| PRODUCT LINE | Signal Transduction |
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| PRODUCT FAMILIES | Phosphoinositide 3-kinase [PI(3)K] / Related Products |
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| Ordering Information |
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| Product Numbers | Format | Size | Unit Price | Quantity | | | ALX-270-465-M001 |
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1 mg | | | | | ALX-270-465-M005 |
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5 mg | | | | | ALX-270-465-M025 |
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25 mg | | | | | | |
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| Product Specification |
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| FORMULA: | C14H8FNO4S |
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| MW: | 305.3 |
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| CAS NUMBER: | 900515-16-4 |
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| PURITY: | ≥98% (1H-NMR) |
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| APPEARANCE: | Yellow to brown crystalline solid. |
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| SOLUBILITY: | Soluble in 100% ethanol (10mg/ml), DMSO (20mg/ml) or dimethyl formamide; also soluble in a 1:1 solution of DMSO:PBS, pH 7.4, (0.5mg/ml). |
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| SHIPPING: | AMBIENT |
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| LONG TERM STORAGE: | -20°C |
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| USE/STABILITY: | Stable for at least 2 years after receip when stored at -20°C. |
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| Product Description |
Potent and selective phosphoinositide 3-kinase (PI(3)K) p110γ inhibitor shown to be selective for class IB PI(3)K-mediated cellular effects. |
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| | Product Specific Literature References | Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils: A.M. Condliffe, et al.; Blood 106, 1432 (2005) Full Text; http://www.bloodjournal.org/cgi/reprint/106/4/1432
Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase gamma: V. Pomel, et al.; J. Med. Chem. 49, 3857 (2006) Full Text; http://pubs.acs.org/cgi-bin/article.cgi/jmcmar/2006/49/i13/pdf/jm0601598.pdf |
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