Bafilomycin A1 |  | | PRODUCT LINE | Natural Products / Antibiotics | | | | PRODUCT FAMILIES | Antibiotics - ATPase Inhibitors | | | | | Ordering Information | | | Product Numbers | Format | Size | Unit Price | Quantity | | | ALX-380-030-C100 |
|
100 µg | | | | | ALX-380-030-M001 |
|
1 mg | | | | | | |
| | | Product Specification | | |
| FORMULA: | C35H58O9 | | | | | |
| MW: | 622.8 | | | | | |
| CAS NUMBER: | 88899-55-2 | | | | | |
| SOURCE/HOST: | Isolated from Streptomyces griseus. | | | | | |
| PURITY: | ≥95% | | | | | |
| APPEARANCE: | White to off-white powder. | | | | | |
| SOLUBILITY: | Soluble in 100% ethanol, methanol or DMSO. | | | | | |
| SHIPPING: | AMBIENT | | | | | |
| LONG TERM STORAGE: | -20°C | | | | | |
| HANDLING: | Protect from light. | | | | | |
| HAZARD: | TOXIC. | | | | | | Product Description | Macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H+-ATPase. Valuable tool for distinguishing among different types of ATPases. Inhibitor of endosomal acidification. |
| | | Product Specific Literature References | Metabolic products of microorganisms. 224. Bafilomycins, a new group of macrolide antibiotics. Production, isolation, chemical structure and biological activity: G. Werner, et al.; J. Antibiot. 37, 110 (1984) Abstract
Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells: E.J. Bowman, et al.; PNAS 85, 7972 (1988) Abstract
The evolution of H+-ATPases [see comments]: N. Nelson & L. Taiz; TIPS 14, 113 (1989), (Review) Abstract
Kinetic studies of chromaffin granule H+-ATPase and effects of bafilomycin A1: H. Hanada, et al.; BBRC 170, 873 (1990) Abstract
Inhibition of osteoclast proton transport by bafilomycin A1 abolishes bone resorption: K. Sundqui, et al.; BBRC 168, 309 (1990) Abstract
The cytotoxic action of diphtheria toxin and its degradation in intact Vero cells are inhibited by bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase: T. Umata, et al.; J. Biol. Chem. 265, 21940 (1990) Full Text; http://www.jbc.org/cgi/reprint/265/35/21940.pdf
Bafilomycin A1 inhibits the targeting of lysosomal acid hydrolases in cultured hepatocytes: K. Oda, et al.; BBRC 178, 369 (1991) Abstract
Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells: T. Yoshimori, et al.; J. Biol. Chem. 266, 17707 (1991) Full Text; http://www.jbc.org/cgi/reprint/266/26/17707.pdf
Inhibitory effect of modified bafilomycins and concanamycins on P- and V-type adenosinetriphosphatases: S. Drose, et al.; Biochemistry 32, 3902 (1993) Abstract
Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, blocks lysosomal cholesterol trafficking in macrophages: T. Furuchi, et al.; J. Biol. Chem. 268, 27345 (1993) Full Text; http://www.jbc.org/cgi/reprint/268/36/27345.pdf
Bafilomycin inhibits proton flow through the H+ channel of vacuolar proton pumps: B.P. Crider, et al.; J. Biol. Chem. 269, 17379 (1994) Full Text; http://www.jbc.org/cgi/reprint/269/26/17379.pdf
Active vacuolar H+ATPase is required for both endocytic and exocytic processes during viral infection of BHK-21 cells: H. Palokangas, et al.; J. Biol. Chem. 269, 17577 (1994) Full Text; http://www.jbc.org/cgi/reprint/269/26/17577.pdf
Inositol trisphosphate-dependent and -independent Ca2+ mobilization pathways at the vacuolar membrane of Candida albicans: C.M. Calvert & D. Sanders; J. Biol. Chem. 270, 7272 (1995) Full Text; http://www.jbc.org/cgi/reprint/270/13/7272
The vacuolar H(+)-ATPase inhibitor bafilomycin A1 differentially affects proteolytic processing of mutant and wild-type beta-amyloid precursor protein: C. Haass, et al.; J. Biol. Chem. 270, 6186 (1995) Full Text; http://www.jbc.org/cgi/reprint/270/11/6186
Cell-type and amyloid precursor protein-type specific inhibition of A beta release by bafilomycin A1, a selective inhibitor of vacuolar ATPases: J. Knops, et al.; J. Biol. Chem. 270, 2419 (1995) Full Text; http://www.jbc.org/cgi/reprint/270/6/2419
Specific inhibitors of vacuolar type H(+)-ATPases induce apoptotic cell death: T. Nishihara, et al.; BBRC 212, 255 (1995) Abstract
Inhibition of mitogen-induced DNA synthesis by bafilomycin A1 in Swiss 3T3 fibroblasts: A.J. Saurin, et al.; Biochem. J. 313, 65 (1996) Abstract
Autophagy, bafilomycin and cell death: the "a-B-cs" of plecomacrolide-induced neuroprotection: J.J. Shacka, et al.; Autophagy 2, 228 (2006), Review Abstract
Bafilomycin A1-sensitive pathway is required for the maturation of cystic fibrosis transmembrane conductance regulator: T. Okiyoneda, et al.; Biochim. Biophys. Acta 1763, 1017 (2006) Abstract |
| | | | | RELATED PRODUCT GROUPS | Signal Transduction > Ion Channels & Transporters / Related Products > ATPases / Related Products > H+-ATPase / Related Products / Cell Death / Apoptosis / Autophagy > Autophagy / Related Products > Autophagy Blockers & Inhibitors / Related Products / Protein Synthesis, Modification & Degradation > Vesicles & Membrane Trafficking > Vesicles & Membrane Trafficking Other Products / Natural Products / Antibiotics > Antibiotics > Antibiotics - Apoptosis Inducers & Inhibitors | | | | | |
