Apg7L (human) (recombinant) (His) |
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| SYNONYMS | Autophagy Protein 7-like (human) (recombinant) (His)
Ubiquitin-activating Enzyme E1-like Protein (human) (recombinant) (His)
Apg Activating Enzyme (human) (recombinant) (His)
ATG7 |
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| PRODUCT LINE | Cell Death / Apoptosis / Autophagy |
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| PRODUCT FAMILIES | Autophagy-related Proteins [APG; ATG] / Related Products |
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| Ordering Information |
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| Product Numbers | Format | Size | Unit Price | Quantity | | | BST-E-317-C025 |
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25 µg | | | | | | |
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| Product Specification |
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| MW: | ~78.9kDa. |
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| PURITY: | ≥95% (SDS-PAGE) |
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| SHIPPING: | SHIPPED ON DRY ICE |
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| LONG TERM STORAGE: | -80°C |
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| HANDLING: | Avoid freeze/thaw cycles. |
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| Product Description |
Autophagy is a process of bulk degradation of cytoplasmic components which are sequestered in double-membrane vesicles (autophagosomes) that deliver the contents to the lysosomal/vacuolar system for degradation. Apg7L is a homodimeric ubiquitin activating E1-like enzyme essential for Apg8 and Apg12 conjugation that mediates membrane fusion in autophagy. This enzyme activates the C-terminal glycine of both ubiquitin-like proteins (UBLs) Apg8 and Apg12 in an ATP-dependent manner. Its activity is essential for the conjugation of Apg8 proteins to the lipid phosphatidylethanolamine (PE), and the conjugation of Apg12L to Apg5L, and is a critical component for the initiation of any in vitro conjugation reactions. |
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| | General Information | |
Background/Technical Information | | Please click here for the Original Manufacturer’s Data Sheet.
Our product description may differ slightly from the Original Manufacturer’s Data Sheet. | | |
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| RELATED PRODUCT GROUPS |
Proteins > Recombinant Proteins / Fusion Proteins / Ubiquitin & Proteasome > Ubiquitination > Ubiquitin-activating Enzymes [E1] |
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