Brefeldin A |  | | PRODUCT LINE | Natural Products / Antibiotics | | | | PRODUCT FAMILIES | Antibiotics - Apoptosis Inducers & Inhibitors | | | | | Ordering Information | | | Product Numbers | Format | Size | Unit Price | Quantity | | | LKT-B6816-M005 |
|
5 mg | | | | | LKT-B6816-M010 |
|
10 mg | | | | | | |
| | | Product Specification | | |
| FORMULA: | C16H24O4 | | | | | |
| MW: | 280.4 | | | | | |
| CAS NUMBER: | 20350-16-6 | | | | | |
| MERCK INDEX: | 13: 1355 | | | | | |
| PURITY: | ≥98% | | | | | |
| LONG TERM STORAGE: | +4°C | | | | | | Product Description | Macrolide isolated from Penicillium brefeldianum possesing antifungal, antiviral an antitumor properties [1]. Affects th golgi apparatus and induces DNA fragmentation which leads to apoptosis [3, 4]. Potent cell cycle modulator that regulates pRB phosphorylation [2]. |
| | | Product Specific Literature References | [1] Novel blockade by brefeldin A of intracellular transport of secretory proteins in cultured rat hepatocytes: Y. Misumi, et al.; J. Biol. Chem. 261, 11398 (1986) Full Text; http://www.jbc.org/cgi/reprint/261/24/11398.pdf
[2] The effects of brefeldin A (BFA) on cell cycle progression involving the modulation of the retinoblastoma protein (pRB) in PC-3 prostate cancer cells: J.A. Mordente, et al.; J. Urol. 159, 275 (1998) Abstract
[3] Golgi complex is brefeldin A resistant in multidrug resistant cells: M.V. Erokhina, et al.; Membr. Cell Biiol. 12, 871 (1999) Abstract
[4] Brefeldin A-induced apoptosis in prostatic cancer DU-145 cells: a possible p53-independent death pathway: J.R. Chapman, et al.; BJU International 83, 703 (1999) Abstract
[5] Induction of terminal differentiation and apoptosis in human colonic carcinoma cells by brefeldin A, a drug affecting ganglioside biosynthesis: H. Nojiri, et al.; FEBS Lett. 453, 140 (1999) Abstract
[6] Production of cyanein by Penicillium simplicissimum: V. Betina, et al.; J. Antibiot. 20, 115 (1966) Abstract |
| | | | | RELATED PRODUCT GROUPS | Natural Products / Antibiotics > Antibiotics > Antibiotics for Cancer Research > Antitumor Antibiotics / Cell Death / Apoptosis / Autophagy > Autophagy / Related Products > Autophagy Other Products / Natural Products / Antibiotics > Antibiotics > Antibiotics - Antiviral / Anti-HIV / Natural Products / Antibiotics > Antibiotics > Antibiotics - Antifungal / Cancer > Antitumor Reagents > Antitumor Agents (Apoptosis Inducers) / Signal Transduction > Ion Channels & Transporters / Related Products > Na+ Channels / Signal Transduction > Ras Signalling Pathway > ADP Ribosylation Factor [ARF] / Related Products / Protein Synthesis, Modification & Degradation > Vesicles & Membrane Trafficking > Golgi Apparatus / Cytoskeleton > Collagen / Related Products | | | | | |
